Department of Pharmacodynamics, Medical University of Lodz, Muszyńskiego 1, 90-151 Łódź, Poland.
Int J Environ Res Public Health. 2023 Jan 18;20(3):1815. doi: 10.3390/ijerph20031815.
Antiepileptic drugs might be useful in the treatment of alcohol use disorder. One of these drugs is zonisamide, which has been found to decrease alcohol intake and cravings. An important structure in the pathophysiology of addiction is the hippocampus. Memory deficits, which frequently occur in alcoholics, are associated with ethanol-induced changes in hippocampal plasticity and neurogenesis. The aim of this study was to assess the potential protective effect of zonisamide on memory in rats receiving alcohol and after the discontinuation of its administration. Wistar rats (n = 43) were tested in four behavioral models, namely: Morris water maze (MWM), passive avoidance (PA), contextual fear conditioning (CFC), and cued fear conditioning (CuFC). Zonisamide co-administered with ethanol impaired spatial memory in MWM, but the drug did not affect memory in PA. However, the beneficial effect of zonisamide was observed after the discontinuation of ethanol administration, which was associated with the improvement of associative memory in CFC and the alleviation of alcohol-induced locomotor disturbances in CuFC. Zonisamide has a differential influence on memory, which depends inter alia on type of the memory, length of ethanol administration, or its absence.
抗癫痫药物可能对治疗酒精使用障碍有用。其中一种药物是佐米曲坦，它已被发现可减少酒精摄入量和渴望。成瘾的病理生理学中的一个重要结构是海马体。记忆缺陷经常发生在酗酒者中，与乙醇引起的海马体可塑性和神经发生变化有关。本研究的目的是评估佐米曲坦对接受酒精和停止给药后大鼠记忆的潜在保护作用。Wistar 大鼠（n = 43）在四个行为模型中进行了测试，即：Morris 水迷宫（MWM）、被动回避（PA）、情境恐惧条件反射（CFC）和线索恐惧条件反射（CuFC）。佐米曲坦与乙醇共同给药会损害 MWM 中的空间记忆，但药物不会影响 PA 中的记忆。然而，在停止乙醇给药后观察到佐米曲坦的有益作用，这与 CFC 中的联想记忆改善和 CuFC 中酒精引起的运动障碍减轻有关。佐米曲坦对记忆有不同的影响，这取决于记忆的类型、乙醇给药的时间长短或是否存在。
