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2000-2015 年美国医生开处羟考酮和其他常用阿片类药物情况。

Physician Dispensing of Oxycodone and Other Commonly Used Opioids, 2000-2015, United States.

机构信息

National Center for Injury Prevention and Control, Centers for Disease Control and Prevention, Atlanta, Georgia.

Office of the Assistant Secretary for Planning and Evaluation, Department of Health and Human Services, Washington, DC, USA.

出版信息

Pain Med. 2018 May 1;19(5):990-996. doi: 10.1093/pm/pnx007.

Abstract

OBJECTIVE

An average of 91 people in the United States die every day from an opioid-related overdose (including prescription opioids and heroin). The direct dispensing of opioids from health care practitioner offices has been linked to opioid-related harms. The objective of this study is to describe the changing nature of the volume of this type of prescribing at the state level.

METHODS

This descriptive study examines the distribution of opioids by practitioners using 1999-2015 Automation of Reports and Consolidated Orders System data. Analyses were restricted to opioids distributed to practitioners. Amount distributed (morphine milligram equivalents [MMEs]) and number of practitioners are presented.

RESULTS

Patterns of distribution to practitioners and the number of practitioners varied markedly by state and changed dramatically over time. Comparing 1999 with 2015, the MME distributed to dispensing practitioners decreased in 16 states and increased in 35. Most notable was the change in Florida, which saw a peak of 8.94 MMEs per 100,000 persons in 2010 (the highest distribution in all states in all years) and a low of 0.08 in 2013.

DISCUSSION

This study presents the first state estimates of office-based dispensing of opioids. Increases in direct dispensing in recent years may indicate a need to monitor this practice and consider whether changes are needed. Using controlled substances data to identify high prescribers and dispensers of opioids, as well as examining overall state trends, is a foundational activity to informing the response to potentially high-risk clinical practices.

摘要

目的

美国平均每天有 91 人死于阿片类药物(包括处方阿片类药物和海洛因)相关的用药过量。医疗保健从业者办公室直接开出阿片类药物与阿片类药物相关伤害有关。本研究的目的是描述这种类型的处方在州一级的数量变化的性质。

方法

本描述性研究使用 1999-2015 年自动化报告和综合订单系统数据,检查从业者开出处方的阿片类药物分布情况。分析仅限于分配给从业者的阿片类药物。呈现分配的数量(吗啡毫克当量 [MME])和从业者数量。

结果

向从业者的分配模式和从业者的数量因州而异,且随时间变化显著。将 1999 年与 2015 年进行比较,16 个州的配药从业者分发的 MME 减少,35 个州增加。最值得注意的是佛罗里达州的变化,该州在 2010 年达到每 10 万人 8.94 MME 的峰值(所有年份所有州的最高分配量),2013 年降至 0.08 的最低点。

讨论

本研究首次提供了州一级办公室开出处方的阿片类药物的估计数。近年来直接分配的增加可能表明需要监测这种做法,并考虑是否需要进行更改。使用受控物质数据来确定高处方和阿片类药物的分配者,以及检查总体州趋势,是为潜在高风险临床实践提供信息的基础活动。

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