*Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health †Center for Drug Safety and Effectiveness, Johns Hopkins University ‡Department of Health Policy and Management, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD §Division of Health Care Policy and Research, Mayo Clinic, Rochester, MN ∥Program on Prevention Outcomes and Practices, Stanford Prevention Research Center, Stanford University School of Medicine, Palo Alto, CA ¶Stefan P. Kruszewski, MD & Associates, Harrisburg, PA #Department of Mental Health, Johns Hopkins Bloomberg School of Public Health **Department of Medicine, Division of General Internal Medicine, Johns Hopkins Medicine, Baltimore, MD.
Med Care. 2013 Oct;51(10):870-8. doi: 10.1097/MLR.0b013e3182a95d86.
Escalating rates of prescription opioid use and abuse have occurred in the context of efforts to improve the treatment of nonmalignant pain.
The aim of the study was to characterize the diagnosis and management of nonmalignant pain in ambulatory, office-based settings in the United States between 2000 and 2010.
DESIGN, SETTING, AND PARTICIPANTS: Serial cross-sectional and multivariate regression analyses of the National Ambulatory Medical Care Survey (NAMCS), a nationally representative audit of office-based physician visits, were conducted.
(1) Annual visit volume among adults with primary pain symptom or diagnosis; (2) receipt of any pain treatment; and (3) receipt of prescription opioid or nonopioid pharmacologic therapy in visits for new musculoskeletal pain.
Primary symptoms or diagnoses of pain consistently represented one-fifth of visits, varying little from 2000 to 2010. Among all pain visits, opioid prescribing nearly doubled from 11.3% to 19.6%, whereas nonopioid analgesic prescribing remained unchanged (26%-29% of visits). One-half of new musculoskeletal pain visits resulted in pharmacologic treatment, although the prescribing of nonopioid pharmacotherapies decreased from 38% of visits (2000) to 29% of visits (2010). After adjusting for potentially confounding covariates, few patient, physician, or practice characteristics were associated with a prescription opioid rather than a nonopioid analgesic for new musculoskeletal pain, and increases in opioid prescribing generally occurred nonselectively over time.
Increased opioid prescribing has not been accompanied by similar increases in nonopioid analgesics or the proportion of ambulatory pain patients receiving pharmacologic treatment. Clinical alternatives to prescription opioids may be underutilized as a means of treating ambulatory nonmalignant pain.
在努力改善非恶性疼痛治疗的背景下,处方类阿片的使用和滥用率不断上升。
本研究旨在描述 2000 年至 2010 年期间,美国非住院、门诊环境中非恶性疼痛的诊断和管理情况。
设计、地点和参与者:对全国门诊医疗调查(NAMCS)进行了一系列的横断面和多元回归分析,该调查是对门诊医生就诊情况的全国代表性审计。
(1)成年人因主要疼痛症状或诊断而就诊的年就诊量;(2)接受任何疼痛治疗的情况;(3)新的肌肉骨骼疼痛就诊时接受处方类阿片或非类阿片药物治疗的情况。
主要疼痛症状或诊断始终占就诊的五分之一,从 2000 年到 2010 年变化不大。在所有疼痛就诊中,阿片类药物的处方量几乎翻了一番,从 11.3%增加到 19.6%,而非阿片类镇痛药的处方量保持不变(26%-29%的就诊)。一半的新发肌肉骨骼疼痛就诊接受了药物治疗,尽管非阿片类药物治疗的处方量从就诊的 38%(2000 年)下降到就诊的 29%(2010 年)。在调整了潜在的混杂因素后,新的肌肉骨骼疼痛就诊时患者、医生或就诊环境的特征很少与开处方类阿片而不是非阿片类镇痛药相关,而且阿片类药物的处方量普遍随着时间的推移非选择性地增加。
阿片类药物的处方量增加并没有伴随着非阿片类镇痛药或接受药物治疗的门诊疼痛患者比例的相应增加。处方类阿片的替代疗法可能在治疗门诊非恶性疼痛方面未得到充分利用。