血管化复合组织异体移植的出现。

The Advent of Vascularized Composite Allotransplantation.

作者信息

Cetrulo Curtis L, Ng Zhi Yang, Winograd Jonathan M, Eberlin Kyle R

机构信息

Division of Plastic and Reconstructive Surgery, Massachusetts General Hospital, 15 Parkman Street, Wang ACC #435, Boston, MA 02114, USA; Vascularized Composite Allotransplantation Laboratory, Center for Transplantation Sciences, Massachusetts General Hospital, Charlestown Navy Yard, Building 149, 13th Street, Suite 9019, Boston, MA 02129, USA.

出版信息

Clin Plast Surg. 2017 Apr;44(2):425-429. doi: 10.1016/j.cps.2016.12.007. Epub 2017 Feb 3.

DOI:10.1016/j.cps.2016.12.007

PMID:28340673

Abstract

Modern microsurgical techniques have made possible a broad spectrum of novel means for the reconstruction of complex bone and soft tissue defects. These techniques, in combination with developments in transplant immunology, have led to successful hand and facial allotransplantation and achievement of the highest rung in the reconstructive ladder - truly replacing like with like. The utilization of contemporary microsurgical technique in the context of vascularized composite allotransplantation (VCA) (1) permits successful technical execution and feasibility of VCA, (2) facilitates the study of immunologic tolerance in VCA preclinical models, and (3) optimizes functional VCA outcomes.

摘要

现代显微外科技术为复杂骨与软组织缺损的重建带来了一系列广泛的新颖方法。这些技术与移植免疫学的发展相结合，已成功实现手部和面部同种异体移植，并达到了重建阶梯的最高水平——真正实现同类组织的替换。在血管化复合组织异体移植（VCA）中应用当代显微外科技术：（1）使VCA在技术上得以成功实施并具备可行性；（2）有助于在VCA临床前模型中研究免疫耐受；（3）优化VCA的功能效果。