Piguet Vincent
Dermatology and Academic Wound Healing, Division of Infection and Immunity, School of Medicine, College of Biomedical and Life Sciences, Cardiff University, Cardiff, UK.
J Invest Dermatol. 2017 Apr;137(4):796-797. doi: 10.1016/j.jid.2017.01.015.
Hyperthermia increases expression of the antiviral cellular factors APOBEC3A and APOBEC3G and induces G-to-A or C-to-T mutations in human papilloma virus cervical cell lines and genital warts. This unexpected effect of heat treatment correlated with regression of genital warts in a subset of patients, including at distant sites, suggesting that this effect may be mediated in part by antiviral as well as immunological mechanisms.
热疗可增加抗病毒细胞因子载脂蛋白B mRNA编辑酶催化多肽样3A（APOBEC3A）和载脂蛋白B mRNA编辑酶催化多肽样3G（APOBEC3G）的表达，并在人乳头瘤病毒宫颈细胞系和尖锐湿疣中诱导G到A或C到T的突变。这种热处理的意外效果与一部分患者（包括远处部位）尖锐湿疣的消退相关，提示这种效果可能部分由抗病毒机制以及免疫机制介导。
