热诱导编辑人乳头瘤病毒基因以清除黏膜皮肤疣？

Heat-Induced Editing of HPV Genes to Clear Mucocutaneous Warts?

作者信息

Piguet Vincent

机构信息

Dermatology and Academic Wound Healing, Division of Infection and Immunity, School of Medicine, College of Biomedical and Life Sciences, Cardiff University, Cardiff, UK.

出版信息

J Invest Dermatol. 2017 Apr;137(4):796-797. doi: 10.1016/j.jid.2017.01.015.

DOI:10.1016/j.jid.2017.01.015

PMID:28340680

Abstract

Hyperthermia increases expression of the antiviral cellular factors APOBEC3A and APOBEC3G and induces G-to-A or C-to-T mutations in human papilloma virus cervical cell lines and genital warts. This unexpected effect of heat treatment correlated with regression of genital warts in a subset of patients, including at distant sites, suggesting that this effect may be mediated in part by antiviral as well as immunological mechanisms.

摘要

热疗可增加抗病毒细胞因子载脂蛋白B mRNA编辑酶催化多肽样3A（APOBEC3A）和载脂蛋白B mRNA编辑酶催化多肽样3G（APOBEC3G）的表达，并在人乳头瘤病毒宫颈细胞系和尖锐湿疣中诱导G到A或C到T的突变。这种热处理的意外效果与一部分患者（包括远处部位）尖锐湿疣的消退相关，提示这种效果可能部分由抗病毒机制以及免疫机制介导。