缺氧诱导因子 1 阿尔法与人类病毒病原体。

Hypoxia inducible factor one alpha and human viral pathogens.

机构信息

Hôpital Saint-Louis, université Paris 7 Paris Diderot, AP-HP, 75010 Paris, France.

Hôpital Ambroise-Paré, université Versailles Saint-Quentin-en-Yvelines, AP-HP, 92100 Boulogne-Billancourt, France.

出版信息

Curr Res Transl Med. 2017 Jan-Mar;65(1):7-9. doi: 10.1016/j.retram.2016.11.002. Epub 2017 Mar 8.

DOI:10.1016/j.retram.2016.11.002

PMID:28340697

Abstract

If the oxygen tension level is 21% in ambient air, it is only between 14% and 1% in vivo. Consequently, viral pathogens are exposed and must adapt to these fluctuating oxygen levels to colonize the host and cause diseases. The problem is that for many years, the virological studies have been performed at 21% oxygen levels and consequently this is a real handicap to have a correct view of the mechanistic aspects of human viral infections. In this brief review, we describe for some selected examples the interactions of human viruses with this relative hypoxia observed in vivo.

摘要

如果环境空气中的氧张力为 21%，那么在体内只有 14%到 1%。因此，病毒病原体暴露于此并必须适应这些波动的氧水平，以定植宿主并引起疾病。问题是，多年来，病毒学研究一直是在 21%的氧水平下进行的，因此这确实是正确了解人类病毒感染的机制方面的一个障碍。在这篇简短的综述中，我们描述了一些选定的例子，说明人类病毒与体内观察到的相对缺氧的相互作用。