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本文引用的文献

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AMP-activated kinase restricts Rift Valley fever virus infection by inhibiting fatty acid synthesis.AMP 激活的蛋白激酶通过抑制脂肪酸合成来限制裂谷热病毒感染。
PLoS Pathog. 2012;8(4):e1002661. doi: 10.1371/journal.ppat.1002661. Epub 2012 Apr 19.
2
Dengue virus infection perturbs lipid homeostasis in infected mosquito cells.登革热病毒感染扰乱了感染蚊细胞中的脂质稳态。
PLoS Pathog. 2012;8(3):e1002584. doi: 10.1371/journal.ppat.1002584. Epub 2012 Mar 22.
3
Metabolism of phosphatidylinositol 4-kinase IIIα-dependent PI4P Is subverted by HCV and is targeted by a 4-anilino quinazoline with antiviral activity.HCV 颠覆了依赖于 PI4KIIIα 的 PI4P 的代谢，而具有抗病毒活性的 4-苯胺基喹唑啉则靶向该代谢途径。
PLoS Pathog. 2012;8(3):e1002576. doi: 10.1371/journal.ppat.1002576. Epub 2012 Mar 8.
4
Visualization and measurement of ATP levels in living cells replicating hepatitis C virus genome RNA.可视化和测量复制丙型肝炎病毒基因组 RNA 的活细胞中的 ATP 水平。
PLoS Pathog. 2012;8(3):e1002561. doi: 10.1371/journal.ppat.1002561. Epub 2012 Mar 1.
5
Host acyl coenzyme A binding protein regulates replication complex assembly and activity of a positive-strand RNA virus.宿主酰基辅酶 A 结合蛋白调节正链 RNA 病毒复制复合物的组装和活性。
J Virol. 2012 May;86(9):5110-21. doi: 10.1128/JVI.06701-11. Epub 2012 Feb 15.
6
Human kinome profiling identifies a requirement for AMP-activated protein kinase during human cytomegalovirus infection.人类激酶组谱分析鉴定出在人类巨细胞病毒感染过程中需要 AMP 激活的蛋白激酶。
Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):3071-6. doi: 10.1073/pnas.1200494109. Epub 2012 Feb 6.
7
HCMV targets the metabolic stress response through activation of AMPK whose activity is important for viral replication.HCMV 通过激活 AMPK 来靶向代谢应激反应，而 AMPK 的活性对于病毒复制很重要。
PLoS Pathog. 2012 Jan;8(1):e1002502. doi: 10.1371/journal.ppat.1002502. Epub 2012 Jan 26.
8
U18666A, an intra-cellular cholesterol transport inhibitor, inhibits dengue virus entry and replication.U18666A，一种细胞内胆固醇转运抑制剂，可抑制登革热病毒进入和复制。
Antiviral Res. 2012 Jan;93(1):191-8. doi: 10.1016/j.antiviral.2011.11.014. Epub 2011 Nov 29.
9
ACBD3-mediated recruitment of PI4KB to picornavirus RNA replication sites.ACBD3 介导 PI4KB 招募到微小 RNA 复制位点。
EMBO J. 2012 Feb 1;31(3):754-66. doi: 10.1038/emboj.2011.429. Epub 2011 Nov 29.
10
Packaging of fat: an evolving model of lipid droplet assembly and expansion.脂肪的包装：脂滴组装和扩展的一个演进模型。
J Biol Chem. 2012 Jan 20;287(4):2273-9. doi: 10.1074/jbc.R111.309088. Epub 2011 Nov 16.

病毒-宿主相互作用界面处的脂质。

Lipids at the interface of virus-host interactions.

机构信息

Department of Microbiology, The University of Chicago, Chicago, IL 60637, United States.

出版信息

Curr Opin Microbiol. 2012 Aug;15(4):512-8. doi: 10.1016/j.mib.2012.05.013. Epub 2012 Jun 9.

DOI:10.1016/j.mib.2012.05.013
PMID:22682978
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3424344/
Abstract

Viruses physically and metabolically remodel the host cell to establish an optimal environment for their replication. Many of these processes involve the manipulation of lipid signaling, synthesis, and metabolism. An emerging theme is that these lipid-modifying pathways are also linked to innate antiviral responses and can be modulated to inhibit viral replication.

摘要

病毒通过物理和代谢方式重塑宿主细胞，为其复制建立最佳环境。其中许多过程涉及脂质信号转导、合成和代谢的操纵。一个新兴主题是，这些脂质修饰途径也与先天抗病毒反应有关，并可通过调节来抑制病毒复制。