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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Pacuła P, Janicki P K, Krzaścik P

Department of Pharmacology, Medical Academy of Warsaw, Poland.

Clin Exp Pharmacol Physiol. 1987 Nov-Dec;14(11-12):911-3. doi: 10.1111/j.1440-1681.1987.tb02427.x.

The effect of opioid receptor blockade by naloxone in vivo on hepatic venous plasma glucose concentration in rats was investigated. 2. The plasma glucose levels in naloxone-injected animals (10 mg/kg) were higher than in the control animals (P less than 0.05). 3. At the lower dose of naloxone (2 mg/kg) the resulting plasma glucose concentration did not differ significantly from control (P greater than 0.1). 4. It is concluded that endogenous opioids may moderate the regulation of basal glucose levels in the rat.

研究了纳洛酮在体内对大鼠肝静脉血浆葡萄糖浓度的阿片受体阻断作用。2. 注射纳洛酮（10毫克/千克）的动物的血浆葡萄糖水平高于对照动物（P小于0.05）。3. 在较低剂量的纳洛酮（2毫克/千克）时，所得血浆葡萄糖浓度与对照无显著差异（P大于0.1）。4. 得出的结论是，内源性阿片类物质可能调节大鼠基础葡萄糖水平。

Pacuła P, Janicki P K, Krzaścik P

Department of Pharmacology, Medical Academy of Warsaw, Poland.

Clin Exp Pharmacol Physiol. 1987 Nov-Dec;14(11-12):911-3. doi: 10.1111/j.1440-1681.1987.tb02427.x.

The effect of opioid receptor blockade by naloxone in vivo on hepatic venous plasma glucose concentration in rats was investigated. 2. The plasma glucose levels in naloxone-injected animals (10 mg/kg) were higher than in the control animals (P less than 0.05). 3. At the lower dose of naloxone (2 mg/kg) the resulting plasma glucose concentration did not differ significantly from control (P greater than 0.1). 4. It is concluded that endogenous opioids may moderate the regulation of basal glucose levels in the rat.

研究了纳洛酮在体内对大鼠肝静脉血浆葡萄糖浓度的阿片受体阻断作用。2. 注射纳洛酮（10毫克/千克）的动物的血浆葡萄糖水平高于对照动物（P小于0.05）。3. 在较低剂量的纳洛酮（2毫克/千克）时，所得血浆葡萄糖浓度与对照无显著差异（P大于0.1）。4. 得出的结论是，内源性阿片类物质可能调节大鼠基础葡萄糖水平。