David P H, Hommel M, Benichou J C, Eisen H A, da Silva L H
Proc Natl Acad Sci U S A. 1978 Oct;75(10):5081-4. doi: 10.1073/pnas.75.10.5081.
The ability of concanavalin A to bind erythrocytes but not malarial parasites was used for the development of a method of merozoite isolation: cells from infected blood were allowed to bind to a column of concanavalin A linked to Sepharose beads and merozoites naturally released by maturation of the schizonts bound to the gel were collected. The principle of this method allows its application to several Plasmodium species. The kinetics of merozoite production and the quality of the preparations (purity, infectivity, and ultrastructural morphology) were investigated by using Plasmodium chabaudi.
伴刀豆球蛋白A能够结合红细胞但不能结合疟原虫，利用这一特性开发了一种裂殖子分离方法：使感染血液中的细胞与连接到琼脂糖珠上的伴刀豆球蛋白A柱结合，收集由成熟裂殖体自然释放并结合到凝胶上的裂殖子。该方法的原理使其可应用于多种疟原虫物种。利用查巴迪疟原虫研究了裂殖子产生的动力学以及制剂的质量（纯度、感染性和超微结构形态）。
