疟原虫与昼夜节律：对一个古老谜题的新见解
Malaria parasites and circadian rhythm: New insights into an old puzzle.
作者信息
Borges-Pereira Lucas, Dias Bárbara K M, Singh Maneesh Kumar, Garcia Celia R S
机构信息
Department of Clinical and Toxicological Analyses, University of São Paulo, São Paulo, Brazil.
Department of Parasitology, University of São Paulo, São Paulo, Brazil.
出版信息
Curr Res Microb Sci. 2020 Dec 14;2:100017. doi: 10.1016/j.crmicr.2020.100017. eCollection 2021 Dec.
Abstract
•Discuss molecular components for the coordination of circadian rhythm of malaria parasites inside the vertebrate host.•Synthetic indole compounds show antimalarial activity against 3D7.• synchronizes in cell culture upon melatonin treatment.
摘要
•讨论脊椎动物宿主体内疟原虫昼夜节律协调的分子成分。
•合成吲哚化合物对3D7显示出抗疟活性。
•褪黑素处理后在细胞培养中同步。
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