Suzuki Daisuke, Matsumoto Satohiro, Mashima Hirosato
Department of Gastroenterology, Saitama Medical Center, Jichi Medical University, Saitama, Japan.
Am J Case Rep. 2017 Mar 25;18:304-307. doi: 10.12659/ajcr.902444.
BACKGROUND Serrated polyposis syndrome (SPS) is characterized by numerous hyperplastic polyps and sessile serrated adenoma/polyp (SSA/P) in the large intestine. SSA/P is known to transform into malignant lesions through the serrated pathway instead of the adenoma-carcinoma sequence. Early diagnosis with lower gastrointestinal endoscopy and early treatment are now considered to be essential. CASE REPORT We had an experience with a case of SPS to which endoscopic treatment was applied in multiple sessions. Endoscopic treatment was performed for 16 lesions in total, and the pathological findings were SSA/P for 15 and adenoma for the other lesion. We intend to continue performing endoscopic surveillance for any newly developing lesions. CONCLUSIONS SPS has a potential for malignant transformation, and issues, such as long-term prognosis and optimal therapeutic strategies, await resolution. However, multiple endoscopic treatments are useful for cases with lesions that are controllable employing this modality.
背景 锯齿状息肉综合征（SPS）的特征是大肠内有大量增生性息肉和无蒂锯齿状腺瘤/息肉（SSA/P）。已知SSA/P通过锯齿状途径而非腺瘤-癌序列转变为恶性病变。目前认为，通过下消化道内镜进行早期诊断和早期治疗至关重要。病例报告 我们有一例SPS患者，接受了多次内镜治疗。总共对16个病变进行了内镜治疗，病理结果为15个是SSA/P，另一个病变是腺瘤。我们打算继续对任何新出现的病变进行内镜监测。结论 SPS有恶变的可能，长期预后和最佳治疗策略等问题有待解决。然而，对于采用这种方式可控制病变的病例，多次内镜治疗是有用的。
