Department of Gastroenterology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Department of Surgery, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Infection. 2017 Oct;45(5):601-606. doi: 10.1007/s15010-017-1012-5. Epub 2017 Mar 24.
Sclerosing encapsulating peritonitis (Abdominal cocoon) is an uncommon cause of intestinal obstruction and tuberculosis is an important etiology. Appropriate management of this entity is still uncertain.
We did a retrospective analysis of patients with abdominal cocoon who were seen over a two year period at a tertiary care center in North India. We included patients with tubercular abdominal cocoon (TAC) who were managed primarily with antitubercular therapy in the present report. The diagnosis of TAC was made using combination of criteria (radiological or surgical findings of cocoon with evidence of tuberculosis in form of microbiological, histological or biochemical evidence). The clinical presentation, outcome and need for surgery for these patients were retrieved from the records of these cases maintained in a database.
Of 18 patients with abdominal cocoon, 15 patients had underlying tuberculosis. The median age was 28 years (interquartile range 24) and 12 (80%) were males. Three patients had confirmed tuberculosis on basis of microbiological evidence. All had abdominal pain for 1-9 months, and 11 had intestinal obstruction. Twelve patients had positive Mantoux test, none had HIV. Pulmonary tuberculosis was noted in four patients, pleural in five, splenic and intestinal in two each, hepatic and mediastinal lymph-nodal in one each. Thirteen patients were started on usual 4-drug anti-tubercular therapy (ATT) while two cirrhotics needed modified ATT. Three patients were on steroids with ATT and all three improved. One patient was lost to follow up. Of the rest 14 patients, 2 underwent surgery, 1 at initial presentation while another after 4 months of ATT. Overall five patients developed intestinal obstruction while on ATT, one needed surgery and one died of liver failure while others improved with conservative means.
TAC can be managed conservatively in a subset of patients.
硬化性包裹性腹膜炎(腹腔茧)是肠梗阻的一种不常见原因,而结核病是重要的病因之一。对于这种疾病,适当的治疗方法仍然存在不确定性。
我们对在印度北部一家三级护理中心就诊的 2 年内患有腹腔茧的患者进行了回顾性分析。我们将主要通过抗结核治疗来管理结核性腹腔茧(TAC)的患者纳入本报告。TAC 的诊断是基于影像学或手术发现茧以及微生物学、组织学或生化证据表明结核病的综合标准做出的。这些患者的临床表现、结局和手术需求是从数据库中保存的这些病例记录中检索出来的。
18 例腹腔茧患者中,有 15 例有基础结核病。中位年龄为 28 岁(四分位间距 24),12 例(80%)为男性。3 例患者通过微生物学证据确诊结核病。所有患者均有 1-9 个月的腹痛,11 例有肠梗阻。12 例患者结核菌素试验阳性,无 HIV 患者。4 例患者有肺结核,5 例患者有胸腔积液,2 例患者有脾和肠结核,1 例患者有肝和纵隔淋巴结结核。13 例患者开始接受通常的 4 药抗结核治疗(ATT),而 2 例肝硬化患者需要修改后的 ATT。3 例患者同时接受 ATT 和类固醇治疗,所有 3 例患者均有所改善。1 例患者失访。其余 14 例患者中,2 例接受了手术,1 例在初始表现时,另 1 例在 ATT 治疗 4 个月后。在 ATT 治疗期间,共有 5 例患者发生肠梗阻,1 例需要手术,1 例因肝功能衰竭死亡,其余患者通过保守治疗得到改善。
TAC 可以在一部分患者中通过保守治疗来管理。