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Pharmacokinetics of linezolid in plasma and cerebrospinal fluid in patients with cerebral hemorrhage post-surgical intervention.

作者信息

Tang Yan, Kong Lingti, Wu Chenchen, Zhang Xiaohua, Lu Guoyu, Wu Xiaofei

机构信息

Department of Emergency Internal Medicine, The First Affiliated Hospital of Bengbu Medical College, Bengbu, 233004, China.

Departmen of Pharmacy, The First Affiliated Hospital of Bengbu Medical College, Bengbu, 233004, China.

出版信息

Eur J Clin Pharmacol. 2017 Jul;73(7):919-921. doi: 10.1007/s00228-017-2239-x. Epub 2017 Mar 24.

DOI:10.1007/s00228-017-2239-x
PMID:28342065
Abstract
摘要

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Pharmacokinetics and pharmacodynamics of linezolid in plasma/cerebrospinal fluid in patients with cerebral hemorrhage after lateral ventricular drainage by Monte Carlo simulation.蒙特卡洛模拟研究脑出血患者侧脑室引流后血浆/脑脊液中利奈唑胺的药代动力学和药效学
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Eur J Clin Pharmacol. 2021 Jan;77(1):79-86. doi: 10.1007/s00228-020-02978-x. Epub 2020 Aug 18.
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J Antimicrob Chemother. 2017 Oct 1;72(10):2817-2822. doi: 10.1093/jac/dkx219.
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Plasma and cerebrospinal fluid concentrations of linezolid in neurosurgical critically ill patients with proven or suspected central nervous system infections.神经外科危重症患者疑似或确诊中枢神经系统感染时，利奈唑胺在其血浆和脑脊液中的浓度。
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Heliyon. 2023 Nov 7;9(11):e21962. doi: 10.1016/j.heliyon.2023.e21962. eCollection 2023 Nov.
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Higher than standard meropenem and linezolid dosages needed for appropriate treatment of an intracerebral hemorrhage patient with augmented renal clearance.对于一名肾清除率增加的脑出血患者，需要高于标准剂量的美罗培南和利奈唑胺进行恰当治疗。
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本文引用的文献

1
Plasma and cerebrospinal fluid concentrations of linezolid in neurosurgical critically ill patients with proven or suspected central nervous system infections.神经外科危重症患者疑似或确诊中枢神经系统感染时，利奈唑胺在其血浆和脑脊液中的浓度。
Int J Antimicrob Agents. 2014 Nov;44(5):409-15. doi: 10.1016/j.ijantimicag.2014.07.001. Epub 2014 Aug 20.
2
Pharmacokinetic/pharmacodynamic evaluation of linezolid in hospitalized paediatric patients: a step toward dose optimization by means of therapeutic drug monitoring and Monte Carlo simulation.利奈唑胺在住院儿科患者中的药代动力学/药效学评价：通过治疗药物监测和蒙特卡罗模拟实现剂量优化的一步。
J Antimicrob Chemother. 2015 Jan;70(1):198-206. doi: 10.1093/jac/dku337. Epub 2014 Sep 1.
3
The efficacy and safety of linezolid and glycopeptides in the treatment of Staphylococcus aureus infections.
利奈唑胺与糖肽类药物治疗金黄色葡萄球菌感染的疗效与安全性。
PLoS One. 2013;8(3):e58240. doi: 10.1371/journal.pone.0058240. Epub 2013 Mar 6.
4
The study of vancomycin use and its adverse reactions associated to patients of a Brazilian university hospital.对巴西一家大学医院患者使用万古霉素及其不良反应的研究。
BMC Res Notes. 2011 Jul 15;4:236. doi: 10.1186/1756-0500-4-236.
5
Vancomycin-associated spontaneous cutaneous adverse drug reactions.万古霉素相关性自发性药物不良反应。
Allergy Asthma Immunol Res. 2011 Jul;3(3):194-8. doi: 10.4168/aair.2011.3.3.194. Epub 2011 May 19.
6
Association of pharmacokinetic and pharmacodynamic aspects of linezolid with infection outcome.利奈唑胺的药代动力学和药效学方面与感染结局的关联。
Curr Drug Metab. 2009 Jan;10(1):2-12. doi: 10.2174/138920009787048446.
7
Benefit-risk assessment of linezolid for serious gram-positive bacterial infections.利奈唑胺用于严重革兰氏阳性菌感染的获益-风险评估
Drug Saf. 2008;31(9):753-68. doi: 10.2165/00002018-200831090-00004.
8
Crystal structure of the oxazolidinone antibiotic linezolid bound to the 50S ribosomal subunit.与50S核糖体亚基结合的恶唑烷酮类抗生素利奈唑胺的晶体结构。
J Med Chem. 2008 Jun 26;51(12):3353-6. doi: 10.1021/jm800379d.
9
Treatment of meningitis caused by methicillin-resistant Staphylococcus aureus with linezolid.利奈唑胺治疗耐甲氧西林金黄色葡萄球菌引起的脑膜炎。
Infection. 2007 Jun;35(4):271-4. doi: 10.1007/s15010-007-6211-z. Epub 2007 Jul 23.
10
Linezolid-induced inhibition of mitochondrial protein synthesis.利奈唑胺诱导的线粒体蛋白质合成抑制。
Clin Infect Dis. 2006 Apr 15;42(8):1111-7. doi: 10.1086/501356. Epub 2006 Mar 13.