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Effect of NCO-700, an inhibitor of thiol protease, on reactive oxygen production by chemotactic peptide-stimulated rabbit peripheral granulocytes.

作者信息

Tawara K, Fujisawa S, Nakai K

机构信息

Department of Pharmacology, Akita University School of Medicine, Japan.

出版信息

Experientia. 1988 Apr 15;44(4):346-7. doi: 10.1007/BF01961277.

DOI:10.1007/BF01961277
PMID:2834217
Abstract

The specific thiol protease inhibitor, NCO-700, which is related to L-trans-epoxysuccinylpeptides, inhibited oxidant production by chemoattractant-stimulated rabbit polymorphonuclear leukocytes. NCO-700 could also scavenge active oxygen generated from sodium hypochlorite-hydrogen peroxide and hypoxanthine-xanthine oxidase systems.

摘要

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2
Long-lived oxidants generated by human neutrophils: characterization and bioactivity.人类中性粒细胞产生的长寿命氧化剂：特性与生物活性
Science. 1983 Nov 11;222(4624):625-8. doi: 10.1126/science.6635660.
3
Inhibition of neutrophil sulfhydryl groups by choloromethyl ketones. A mechanism for their inhibition of superoxide production.氯甲基酮对中性粒细胞巯基的抑制作用。其抑制超氧化物产生的机制。
Biochem Biophys Res Commun. 1983 Apr 29;112(2):671-7. doi: 10.1016/0006-291x(83)91515-2.
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Reduction of experimentally produced acute myocardial infarction size by a new synthetic inhibitor, NCO-700, against calcium-activated neutral protease.
Jpn Heart J. 1982 Sep;23(5):829-34. doi: 10.1536/ihj.23.829.
5
Association of neutrophil chemiluminescence with microbicidal activity.中性粒细胞化学发光与杀菌活性的关联。
Clin Immunol Immunopathol. 1982 Feb;22(2):259-69. doi: 10.1016/0090-1229(82)90042-3.
6
Monocyte and granulocyte-mediated tumor cell destruction. A role for the hydrogen peroxide-myeloperoxidase-chloride system.单核细胞和粒细胞介导的肿瘤细胞破坏。过氧化氢-髓过氧化物酶-氯化物系统的作用。
J Clin Invest. 1982 Feb;69(2):255-62. doi: 10.1172/jci110447.
7
A potential role for hypochlorous acid in granulocyte-mediated tumor cell cytotoxicity.次氯酸在粒细胞介导的肿瘤细胞细胞毒性中的潜在作用。
Blood. 1980 Feb;55(2):347-50.
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J Clin Invest. 1980 Jan;65(1):74-81. doi: 10.1172/JCI109662.
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Generation of nitrogen-chlorine oxidants by human phagocytes.人类吞噬细胞产生氮氯氧化剂。
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