Peterse J L, van Dongen J A, Bartelink H
Department of Pathology, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Huis, Amsterdam.
Eur J Surg Oncol. 1988 Apr;14(2):123-6.
Clinicopathologic data were analysed of 15 patients with recurrence of carcinoma after breast conserving treatment and who underwent salvage mastectomy with curative intent. Twelve recurred in the same site as the original tumor after an average interval of 29 months; the remaining three arose elsewhere in the breast after an average, 83 months. Ten patients presented with palpable lumps, one with Paget's disease of the nipple and four with mammographical microcalcifications. Thirteen patients are alive without evidence of disease (mean follow-up 20 months), one patient died of chest wall recurrence 10 months after mastectomy and one is alive with metastatic disease 9 months after mastectomy. Extensive ductal carcinoma in situ, which was found in 53% of the initial excisions in this series, may be associated with a high risk of local recurrence.
对15例保乳治疗后出现癌症复发并接受了根治性挽救性乳房切除术的患者的临床病理数据进行了分析。12例在平均29个月的间隔后于原肿瘤相同部位复发；其余3例在平均83个月后于乳房其他部位出现复发。10例患者可触及肿块，1例患有乳头派杰病，4例有乳腺钼靶微钙化。13例患者存活且无疾病证据（平均随访20个月），1例患者在乳房切除术后10个月死于胸壁复发，1例患者在乳房切除术后9个月因转移性疾病存活。本系列中53%的初次切除标本中发现有广泛导管原位癌，其可能与局部复发的高风险相关。
