甲状腺激素和睾酮对印度蜓蜥（变色树蜥）肝脏线粒体酶活性的影响。

Influence of thyroid hormones and testosterone on the activities of hepatic mitochondrial enzymes in the Indian garden lizard, Calotes versicolor.

作者信息

Oommen O V, Sreedeviamma K K

机构信息

Department of Zoology, University of Kerala, Trivandrum, India.

出版信息

Gen Comp Endocrinol. 1988 Mar;69(3):391-8. doi: 10.1016/0016-6480(88)90030-5.

DOI:10.1016/0016-6480(88)90030-5

PMID:2834260

Abstract

Thyroidectomy and castration in Calotes versicolor significantly decreased the activities of hepatic mitochondrial cytochrome oxidase, alpha-glycerophosphate dehydrogenase (alpha-GPDH), and succinate dehydrogenase (SDH) when compared to sham-operated controls. Administration of thyroid hormones in thyroidectomized lizards and testosterone in castrated specimens stimulated the activities of all three enzymes studied. Chloramphenicol, when injected with thyroxine prevented the hormone-stimulated activities of cytochrome oxidase and SDH, while actinomycin D and chloramphenicol, when administered along with testosterone propionate (low dose) prevented the testosterone-stimulated activities of cytochrome oxidase and alpha-GPDH.

摘要

与假手术对照组相比，变色树蜥的甲状腺切除术和去势术显著降低了肝脏线粒体细胞色素氧化酶、α-甘油磷酸脱氢酶（α-GPDH）和琥珀酸脱氢酶（SDH）的活性。给甲状腺切除的蜥蜴注射甲状腺激素以及给去势标本注射睾酮，可刺激所研究的这三种酶的活性。当与甲状腺素一起注射时，氯霉素可阻止激素刺激的细胞色素氧化酶和SDH的活性，而当与丙酸睾酮（低剂量）一起给药时，放线菌素D和氯霉素可阻止睾酮刺激的细胞色素氧化酶和α-GPDH的活性。