甲状腺激素对无足两栖动物卡氏格氏蚓螈（贝德姆）氧化代谢的刺激作用。

Stimulation of oxidative metabolism by thyroid hormones in an apodan amphibian, Gegenophis carnosus (Beddome).

作者信息

Sutharam K K, Peter M C, Oommen O V

机构信息

Department of Zoology, University of Kerala, Trivandrum, India.

出版信息

Gen Comp Endocrinol. 1990 Aug;79(2):246-52. doi: 10.1016/0016-6480(90)90110-8.

DOI:10.1016/0016-6480(90)90110-8

PMID:2167865

Abstract

Administration of different doses of L-thyroxine (T4) and triiodo-L-thyronine (T3) in vivo in G. carnosus stimulated the activities of cytochrome oxidase, alpha-glycerophosphate dehydrogenase (alpha-GPDH), succinate dehydrogenase (SDH), and Mg2+ adenosine triphosphatase (Mg2+ ATPase) and inhibited the activity of malate dehydrogenase (MDH). While a low dose of thiouracil administration produced a stimulatory effect on cytochrome oxidase and alpha-GPDH activities, a higher dose of thiouracil significantly inhibited the activities of cytochrome oxidase, alpha-GPDH, SDH, Mg2+ ATPase, and MDH. Injection of T4 or T3 into thiouracil-treated animals significantly restored the stimulatory effect of thyroid hormones on oxidative enzyme activities. It is suggested that thyroid hormones in vivo increase and that thiouracil decreases the oxidative capacity of hepatic mitochondria of G. carnosus.

摘要

给肉食性盖氏鲈体内注射不同剂量的L-甲状腺素（T4）和三碘-L-甲状腺原氨酸（T3），刺激了细胞色素氧化酶、α-甘油磷酸脱氢酶（α-GPDH）、琥珀酸脱氢酶（SDH）和Mg2+腺苷三磷酸酶（Mg2+ATPase）的活性，并抑制了苹果酸脱氢酶（MDH）的活性。低剂量硫脲给药对细胞色素氧化酶和α-GPDH活性产生刺激作用，而高剂量硫脲则显著抑制细胞色素氧化酶、α-GPDH、SDH、Mg2+ATPase和MDH的活性。给硫脲处理的动物注射T4或T3可显著恢复甲状腺激素对氧化酶活性的刺激作用。提示体内甲状腺激素增加，而硫脲降低了肉食性盖氏鲈肝线粒体的氧化能力。