Xiao Wenhuan, Ye Fei, Liu Chunlai, Tang Xiaowei, Li Jin, Dong Hui, Sha Weiwei, Zhang Xiaobin
Department of Psychiatry, Affiliated WuTaiShan Hospital of Medical College of Yangzhou University, Yangzhou 225003, PR China.
Department of Psychiatry, Affiliated Kangren Hospital, Ili Kazak Autonomous Prefecture of Xinjiang 835000, PR China.
Prog Neuropsychopharmacol Biol Psychiatry. 2017 Jun 2;76:163-168. doi: 10.1016/j.pnpbp.2017.03.013. Epub 2017 Mar 22.
Evidence suggests that brain-derived neurotrophic factor (BDNF) and glial cell line -derived neurotrophic factor (GDNF) are important in the regulation of synaptic plasticity, which plays a key role in the cognitive processes in psychiatric disorders. Our work aimed at exploring the associations between serum BDNF and GDNF levels and cognitive functions in first-episode drug-naïve (FEDN) patients with schizophrenia.
The BDNF and GDNF levels of 58 FEDN patients and 55 age- and sex-matched healthy controls were measured and test subjects were examined using several neurocognitive tests including the verbal fluency test (VFT), the trail making test (TMT), the digit span test (DST), and the Stroop test.
Patients performed significantly worse than controls in nearly all neurocognitive performances except the forward subscale part of the DST. BDNF levels were inversely correlated to TMT-part B scores and positively correlated to VFT-action in the FEDN group. GDNF levels showed a positive correlation with VFT-action scores and a negative correlation with TMT-part B scores of these patients.
Current data suggests that cognitive dysfunction widely exists in the early stages of schizophrenia. BDNF and GDNF may be jointly contributed to the pathological mechanisms involved in cognitive impairment in FEDN patients with schizophrenia.
有证据表明，脑源性神经营养因子（BDNF）和胶质细胞系源性神经营养因子（GDNF）在突触可塑性调节中起重要作用，而突触可塑性在精神疾病的认知过程中起关键作用。我们的研究旨在探讨首发未用药的精神分裂症患者血清BDNF和GDNF水平与认知功能之间的关联。
测量了58例首发未用药患者和55例年龄及性别匹配的健康对照者的BDNF和GDNF水平，并使用多种神经认知测试对受试者进行检查，包括言语流畅性测试（VFT）、连线测验（TMT）、数字广度测试（DST）和斯特鲁普测试。
除DST的顺背分量表部分外，患者在几乎所有神经认知表现方面均显著差于对照组。在首发未用药组中，BDNF水平与TMT-B部分得分呈负相关，与VFT-动作呈正相关。这些患者的GDNF水平与VFT-动作得分呈正相关，与TMT-B部分得分呈负相关。
目前的数据表明，认知功能障碍在精神分裂症早期广泛存在。BDNF和GDNF可能共同参与了首发未用药的精神分裂症患者认知障碍的病理机制。
