Zhang Peiyun, Chen Lingyun, Qin Qianqian, Liu Chao, Zhu Haijiao, Hu Wenqing, He Xinyu, Tang Kaihong, Yan Qi, Shen Hongmei
Laboratory of Biological Psychiatry, Nantong Mental Health Center, Nantong Brain Hospital & Affiliated Mental Health Center of Nantong University, Nantong, China.
Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, China.
Front Psychiatry. 2025 Jan 16;15:1477285. doi: 10.3389/fpsyt.2024.1477285. eCollection 2024.
Negative and cognitive symptoms present significant challenges in patients with schizophrenia, and cognitive remediation is a promising approach to alleviate these symptoms. This study aimed to explore the efficacy of computerized cognitive remediation therapy (CCRT) on psychiatric symptoms, cognitive deficits, and serum levels of brain-derived neurotrophic factor (BDNF) and glial cell line-derived neurotrophic factor (GDNF) in patients with schizophrenia.
Forty male long-term institutionalized inpatients with schizophrenia were assigned to either a CCRT group (n = 20) or a control group (n = 20). The CCRT intervention consisted of 40 individual 40-min sessions over 8 weeks, conducted five times a week. Psychiatric symptoms, cognition, and serum levels of BDNF and GDNF were assessed at baseline, 4 weeks, and 8 weeks.
Compared to the control group, the CCRT group exhibited decreased total Positive and Negative Syndrome Scale and negative subscale scores, as well as increased Montreal Cognitive Assessment and Repeatable Battery for the Assessment of Neuropsychological Status scores. Moreover, improvements in list recall were associated with reduced negative symptoms. Additionally, CCRT ameliorated the decrease in serum GDNF levels in patients with schizophrenia.
The effectiveness of CCRT in alleviating negative symptoms was associated with improvements in list recall, and GDNF may play a role in the observed effects of CCRT in patients with schizophrenia.
阴性症状和认知症状给精神分裂症患者带来了重大挑战，认知康复是缓解这些症状的一种有前景的方法。本研究旨在探讨计算机化认知康复治疗（CCRT）对精神分裂症患者精神症状、认知缺陷以及脑源性神经营养因子（BDNF）和胶质细胞源性神经营养因子（GDNF）血清水平的疗效。
40名长期住院的男性精神分裂症患者被分为CCRT组（n = 20）和对照组（n = 20）。CCRT干预包括在8周内进行40次每次40分钟的个体治疗，每周进行5次。在基线、4周和8周时评估精神症状、认知以及BDNF和GDNF的血清水平。
与对照组相比，CCRT组的阳性和阴性症状量表总分及阴性分量表得分降低，蒙特利尔认知评估量表和可重复神经心理状态评估量表得分升高。此外，列表回忆的改善与阴性症状的减轻相关。此外，CCRT改善了精神分裂症患者血清GDNF水平的下降。
CCRT缓解阴性症状的有效性与列表回忆的改善有关，GDNF可能在CCRT对精神分裂症患者的观察效果中起作用。
