Nejati-Koshki Kazem, Mortazavi Yousef, Pilehvar-Soltanahmadi Younes, Sheoran Sumit, Zarghami Nosratollah
Department of Medical Biotechnology and Nanotechnology, Faculty of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran.
Department of Medical Biotechnology and Nanotechnology, Faculty of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran; Cancer Gene Therapy Research Center, Zanjan University of Medical Sciences, Zanjan, Iran.
Biomed Pharmacother. 2017 Jun;90:85-92. doi: 10.1016/j.biopha.2017.03.035. Epub 2017 Mar 24.
Spinal cord injury (SCI) is damage to the spinal cord that leads to sudden loss of motor and autonomic function and sensory under the level of the injury. The pathophysiological advancement of SCI is divided into two categories: primary injury and secondary injury. Due to the loss of motor, sensory, or cognitive function, a patient's quality of life is likely reduced and places a great burden on society in order to supply health care costs. Therefore, it is important to develop suitable therapeutic strategies for SCI therapy. Nano biomedical systems and stem cell based therapy have the potential to provide new therapeutic availability and efficacy over conventional medicine. Due to their unique properties, nanomaterials and mesenchymal stem cells can be used to offer efficient treatments. Nanoparticles have a potential to deliver therapeutic molecules to the target tissue of interest, reducing side effects of untargeted therapies in unwanted areas. Mesenchymal stem cells (MSCs) can reduce activating inflammation responses that lead to cell death and promote functional recovery and cell growth. We review recent uses of nanomaterials and stem cells in regeneration of SCI.
脊髓损伤（SCI）是指脊髓受到损伤，导致损伤平面以下突然出现运动、自主神经功能及感觉丧失。SCI的病理生理进展分为两类：原发性损伤和继发性损伤。由于运动、感觉或认知功能丧失，患者的生活质量可能会降低，并且为提供医疗保健费用给社会带来了巨大负担。因此，开发适用于SCI治疗的策略很重要。纳米生物医学系统和基于干细胞的疗法有可能比传统医学提供新的治疗可用性和疗效。由于其独特的性质，纳米材料和间充质干细胞可用于提供有效的治疗。纳米颗粒有潜力将治疗分子递送至感兴趣的靶组织，减少非靶向治疗在非靶区域的副作用。间充质干细胞（MSCs）可以减少导致细胞死亡的激活炎症反应，并促进功能恢复和细胞生长。我们综述了纳米材料和干细胞在SCI再生中的最新应用。
