Aziz Sadia, Anbreen Sundus, Shahzad Shaheen, Ahmed Muhammad Saad, Sharma Vivek, Yang Jing, Ali Liaqat
Department of Biological Sciences, International Islamic University Islamabad, Pakistan.
Department of Biotechnology,Quaid I Azam University Islamabad, Pakistan.
Am J Stem Cells. 2025 Apr 15;14(1):1-13. doi: 10.62347/YGYM4976. eCollection 2025.
Stem cell therapy is a promising area of regenerative medicine, offering potential treatments for various life-threatening disorders. Stem cells are classified based on their differentiation potential into totipotent, pluripotent, and multipotent stem cells. Among them, mesenchymal stem cells (MSCs) are widely used in regenerative medicine due to their tissue regeneration capabilities and ability to differentiate into multiple cell types. Stem cells are being explored for treating neurodegenerative disorders like Parkinson's, Alzheimer's, Huntington's, and amyotrophic lateral sclerosis (ALS). These conditions result from progressive neuronal degeneration, leading to irreversible damage. Challenges such as cell survival, immune rejection, tumor formation, and ethical concerns related to embryonic stem cells need to be addressed. Nanotechnology is emerging as a tool for enhancing stem cell therapy, improving targeted delivery and effectiveness. Nanoparticles possess the ability to create microenvironments as substrates, facilitate targeted administration, and enable real-time, precise imaging of stem cells. This review explores the integration of stem cells and nanotechnology as regenerative medicine tool for neurodegenerative disease treatment, analyzing current strategies and therapeutic approaches. Integrating nanotechnology with stem cell therapy may significantly improve targeted delivery and enhance regenerative outcomes for neurodegenerative disorders.
干细胞疗法是再生医学中一个很有前景的领域，为各种危及生命的疾病提供了潜在的治疗方法。干细胞根据其分化潜能可分为全能干细胞、多能干细胞和多能干细胞。其中，间充质干细胞（MSCs）因其组织再生能力和分化为多种细胞类型的能力而被广泛应用于再生医学。目前正在探索利用干细胞治疗帕金森氏症、阿尔茨海默氏症、亨廷顿氏症和肌萎缩侧索硬化症（ALS）等神经退行性疾病。这些病症是由进行性神经元变性引起的，会导致不可逆转的损伤。诸如细胞存活、免疫排斥、肿瘤形成以及与胚胎干细胞相关的伦理问题等挑战需要得到解决。纳米技术正在成为一种增强干细胞疗法、改善靶向递送和有效性的工具。纳米颗粒有能力创建作为基质的微环境、促进靶向给药，并能够对干细胞进行实时、精确的成像。这篇综述探讨了干细胞与纳米技术作为治疗神经退行性疾病的再生医学工具的整合，分析了当前的策略和治疗方法。将纳米技术与干细胞疗法相结合可能会显著改善靶向递送，并提高神经退行性疾病的再生效果。
