选择性地增强背侧流中的θ振荡可使听觉工作记忆性能得到因果提升。
Selective Entrainment of Theta Oscillations in the Dorsal Stream Causally Enhances Auditory Working Memory Performance.
机构信息
Cognitive Neuroscience Unit, Montreal Neurological Institute, McGill University, Montreal, QC H3A 2B4, Canada; McConnell Brain Imaging Center, Montreal Neurological Institute, McGill University, Montreal, QC H3A 2B4, Canada; International Laboratory for Brain, Music and Sound Research (BRAMS), Montreal, QC H2V 2J2, Canada.
Cognitive Neuroscience Unit, Montreal Neurological Institute, McGill University, Montreal, QC H3A 2B4, Canada; McConnell Brain Imaging Center, Montreal Neurological Institute, McGill University, Montreal, QC H3A 2B4, Canada.
出版信息
Neuron. 2017 Apr 5;94(1):193-206.e5. doi: 10.1016/j.neuron.2017.03.015. Epub 2017 Mar 23.
The implication of the dorsal stream in manipulating auditory information in working memory has been recently established. However, the oscillatory dynamics within this network and its causal relationship with behavior remain undefined. Using simultaneous MEG/EEG, we show that theta oscillations in the dorsal stream predict participants' manipulation abilities during memory retention in a task requiring the comparison of two patterns differing in temporal order. We investigated the causal relationship between brain oscillations and behavior by applying theta-rhythmic TMS combined with EEG over the MEG-identified target (left intraparietal sulcus) during the silent interval between the two stimuli. Rhythmic TMS entrained theta oscillation and boosted participants' accuracy. TMS-induced oscillatory entrainment scaled with behavioral enhancement, and both gains varied with participants' baseline abilities. These effects were not seen for a melody-comparison control task and were not observed for arrhythmic TMS. These data establish theta activity in the dorsal stream as causally related to memory manipulation. VIDEO ABSTRACT.
背侧流在工作记忆中操纵听觉信息的意义最近已经确立。然而，该网络内的振荡动力学及其与行为的因果关系仍未定义。使用同时进行的 MEG/EEG，我们表明在需要比较两个在时间顺序上不同的模式的任务中，背侧流中的θ振荡可以预测参与者在记忆保持期间的操作能力。我们通过在两个刺激之间的静默间隔期间应用θ节律 TMS 结合 EEG 来调查脑振荡和行为之间的因果关系，该 TMS 应用于 MEG 识别的目标（左顶内沟）上。节律 TMS 使θ振荡同步，并提高了参与者的准确性。TMS 诱导的振荡同步与行为增强成正比，并且增益随参与者的基线能力而变化。这些效果在旋律比较控制任务中没有看到，也没有在非节律 TMS 中观察到。这些数据将背侧流中的θ活动确立为与记忆操作有因果关系。视频摘要。
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