Clinic for Gynecology, Martin Luther University Halle-Wittenberg, Germany.
Semin Cancer Biol. 2017 Jun;44:72-82. doi: 10.1016/j.semcancer.2017.03.006. Epub 2017 Mar 23.
Breast cancer is a systemic disease characterized by early dissemination of tumor cells to distant organs. In this foreign environment, tumor cells may stay in a dormant state as single cells or as micrometastases for many years before growing out into a macrometastatic lesion. As metastasis is the primary cause for breast cancer-related death, it is important to understand the mechanisms underlying the maintenance of dormancy and dormancy escape to find druggable targets to eradicate metastatic tumor cells. Metastatic dormancy is regulated by complex interactions between tumor cells and the local microenvironment. In addition, cancer-directed immunity and systemic instigation play a crucial role.
乳腺癌是一种全身性疾病，其特征是肿瘤细胞早期向远处器官播散。在这种异质环境中，肿瘤细胞可能以单细胞或微转移灶的形式处于休眠状态多年，然后才发展为大转移病灶。由于转移是乳腺癌相关死亡的主要原因，因此了解休眠和休眠逃逸的维持机制对于寻找可消除转移性肿瘤细胞的药物靶点非常重要。转移休眠受肿瘤细胞与局部微环境之间复杂相互作用的调节。此外，肿瘤定向免疫和全身激发也起着至关重要的作用。
