Dillekås Hanna, Straume Oddbjørn
Department of Clinical Science, University of Bergen, N5020, Bergen, Norway.
Centre for Cancer Biomarkers CCBIO, Department of Clinical Medicine, University of Bergen, N5020, Bergen, Norway; Department of Oncology and Medical Physics, Haukeland University Hospital, N5021, Bergen, Norway.
Surg Oncol. 2019 Mar;28:50-56. doi: 10.1016/j.suronc.2018.11.009. Epub 2018 Nov 9.
Tumor dormancy is considered one of the major unsolved questions in cancer biology. Understanding the mechanisms responsible for maintaining and interrupting dormancy would be a major step towards preventing overt metastatic disease. Increasing evidence points to tissue trauma and subsequent wound healing as contributing events in escape from dormancy. In this review, we outline relevant aspects of the wound healing process, and relate this to mechanisms of tumor dormancy and metastatic progression. In addition to important findings in epidemiological and experimental studies, more direct evidence of such a link has recently been presented. These results can have major implications for treatment and prevention of cancer.
肿瘤休眠被认为是癌症生物学中尚未解决的主要问题之一。了解维持和打破休眠的机制将是预防明显转移性疾病的重要一步。越来越多的证据表明，组织创伤及随后的伤口愈合是肿瘤从休眠状态逃逸的促成因素。在本综述中，我们概述了伤口愈合过程的相关方面，并将其与肿瘤休眠和转移进展的机制联系起来。除了流行病学和实验研究中的重要发现外，最近还出现了这种联系的更直接证据。这些结果可能对癌症的治疗和预防产生重大影响。
