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新型2,5-二取代-1,3,4-恶二唑衍生物的合成、表征及生物学评价

Synthesis, characterization and biological evaluation of novel 2,5 substituted-1,3,4 oxadiazole derivatives.

作者信息

Kavitha Selvaraj, Kannan Kulanthai, Gnanavel Sadhasivam

机构信息

Department of Chemistry, Government College of Engineering, Salem 11, Tamil Nadu, India.

出版信息

Saudi Pharm J. 2017 Mar;25(3):337-345. doi: 10.1016/j.jsps.2016.07.004. Epub 2016 Aug 1.

DOI:10.1016/j.jsps.2016.07.004
PMID:28344487
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5357090/
Abstract

In the present study, a series of 3-(5-cyclohexyl-1,3,4-oxadiazol-2-yl)-N-substituted aniline have been synthesized by multistep reaction scheme. Benzohydrazide was used as the starting material. The structures of all synthesized compounds are characterized and confirmed by FT-IR, H and C NMR and mass spectral studies with the intention of developing the novel biologically active compounds. All title synthetic compounds were screened for their antidiabetic, anti-inflammatory and anticancer activities.

摘要

在本研究中，通过多步反应方案合成了一系列3-(5-环己基-1,3,4-恶二唑-2-基)-N-取代苯胺。以苯甲酰肼为起始原料。通过傅里叶变换红外光谱（FT-IR）、氢核磁共振（H NMR）、碳核磁共振（C NMR）和质谱研究对所有合成化合物的结构进行了表征和确认，旨在开发新型生物活性化合物。对所有标题合成化合物进行了抗糖尿病、抗炎和抗癌活性筛选。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8eaf/5357090/829df5694690/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8eaf/5357090/ea225394b655/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8eaf/5357090/14b0f6089b8f/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8eaf/5357090/e7cd1088575a/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8eaf/5357090/95b02876fbd7/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8eaf/5357090/655f531e7f8d/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8eaf/5357090/038d2a70330f/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8eaf/5357090/829df5694690/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8eaf/5357090/ea225394b655/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8eaf/5357090/14b0f6089b8f/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8eaf/5357090/e7cd1088575a/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8eaf/5357090/95b02876fbd7/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8eaf/5357090/655f531e7f8d/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8eaf/5357090/038d2a70330f/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8eaf/5357090/829df5694690/gr5.jpg

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