抗真菌烯丙胺类药物“特比萘芬”的新微生物来源。

New microbial source of the antifungal allylamine "Terbinafine".

作者信息

Abdel-Kader Maged S, Muharram Magdy M

机构信息

Department of Pharmacognosy, College of Pharmacy, Prince Sattam Bin Abdulaziz University, 11942 Alkharj, Saudi Arabia; Department of Pharmacognosy, College of Pharmacy, Alexandria University, Alexandria 21215, Egypt.

Department of Pharmacognosy, College of Pharmacy, Prince Sattam Bin Abdulaziz University, 11942 Alkharj, Saudi Arabia; Department of Microbiology, College of Science, Al-Azhar University, Nasr City, 11884 Cairo, Egypt.

出版信息

Saudi Pharm J. 2017 Mar;25(3):440-442. doi: 10.1016/j.jsps.2016.06.006. Epub 2016 Jun 24.

DOI:10.1016/j.jsps.2016.06.006

PMID:28344499

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5357105/

Abstract

The isolated active compound "F12" from the culture media of the sp. KH-F12 was identified using different spectroscopic techniques. Both 1D- and 2D-NMR as well as HRESIMS were utilized to characterize the structure of the isolated compound. 'F12" was found to be the known systemic antifungal drug terbinafine marketed under the name "Lamisil". Full analysis of the COSY, HSQC and HMBC enables the full assignment of proton and carbon atoms. Terbinafine is a synthetic allylamine and is reported here for the first time from natural source.

摘要

从sp. KH - F12的培养基中分离出的活性化合物“F12”，通过不同的光谱技术进行了鉴定。利用一维和二维核磁共振以及高分辨电喷雾电离质谱来表征分离出的化合物的结构。发现“F12”是一种已知的全身用抗真菌药物特比萘芬，商品名为“兰美抒”。对化学全相关谱、异核单量子相干谱和异核多键相关谱的全面分析，能够对质子和碳原子进行完全归属。特比萘芬是一种合成的烯丙胺，本文首次报道其来源于天然来源。