Zarei Mahmoudabadi A, Seifi Z, Gharaghani M
Department of Medical Mycology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Health Research Institute, Infectious and Tropical Diseases Research Centre, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Curr Med Mycol. 2015 Mar;1(1):18-21. doi: 10.18869/acadpub.cmm.1.1.18.
Otomycosis is an acute, subacute or chronic fungal infection of the pinna, the external auditory meatus and the ear canal caused mainly by several species of saprophytic fungi. Lamisil (Terbinafine) is an allylamine antifungal agent, that is used both in the topical and oral administration for the treatment of dermatophytosis, cutaneous candidiasis, and the pityriasis versicolor. We investigated the activity of clotrimazole, miconazole, nystatin, and Lamisil against the agents of otomycosis.
Fifteen clinically obtained isolates from otomycosis ( species; n=13, and species, n=2) and 8 environmental isolates of were tested. The disk diffusion method was employed to detect susceptibility. In the present study, the activity of the terbinafine with clotrimazole, miconazole, and nystatin against several isolates of and with different sources were compared.
Out of 23 isolates of , 4(17.4%) and 1(4.4%) were resistant to nystatin and miconazole, respectively. In addition, all tested organisms were sensitive to clotrimazole and terbinafine. Statistical analysis has shown that there are no significant differences on the effects of clotrimazole, miconazole and, terbinafine on saprophytic (environmental) and pathogenic isolates of , , and (P value= 0.85). In addition, all tested organisms were found to be highly susceptible to terbinafine (P< 0.04).
This is a new approach for the possible use of Lamisil for the treatment of otomycosis
耳霉菌病是一种主要由几种腐生真菌引起的耳廓、外耳道和耳道的急性、亚急性或慢性真菌感染。兰美抒（特比萘芬）是一种烯丙胺类抗真菌药，可用于局部和口服治疗皮肤癣菌病、皮肤念珠菌病和花斑癣。我们研究了克霉唑、咪康唑、制霉菌素和兰美抒对耳霉菌病病原体的活性。
对15株临床分离的耳霉菌病菌株（13株 种，2株 种）和8株环境分离的 菌株进行了测试。采用纸片扩散法检测药敏性。在本研究中，比较了特比萘芬与克霉唑、咪康唑和制霉菌素对不同来源的几种 和 菌株的活性。
在23株 菌株中，4株（17.4%）对制霉菌素耐药，1株（4.4%）对咪康唑耐药。此外，所有受试菌株对克霉唑和特比萘芬敏感。统计分析表明，克霉唑、咪康唑和特比萘芬对腐生（环境）和致病性 、 和 菌株的作用无显著差异（P值 = 0.85）。此外，所有受试菌株对特比萘芬高度敏感（P < 0.04）。
这是一种可能使用兰美抒治疗耳霉菌病的新方法。
