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Proarrhythmogenic effects of lamotrigine during ajmaline testing for Brugada syndrome.

作者信息

Leong Kevin M W, Seligman Henry, Varnava Amanda M

机构信息

Imperial College Healthcare NHS Trust, London, United Kingdom.

West Hertfordshire Hospitals NHS Trust, Watford, United Kingdom.

出版信息

HeartRhythm Case Rep. 2017 Jan 22;3(3):167-171. doi: 10.1016/j.hrcr.2016.11.006. eCollection 2017 Mar.

DOI:10.1016/j.hrcr.2016.11.006
PMID:28344931
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5353681/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1279/5420073/6fd331e429f0/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1279/5420073/f4beb1d53144/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1279/5420073/da49c36fd41f/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1279/5420073/6fd331e429f0/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1279/5420073/f4beb1d53144/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1279/5420073/da49c36fd41f/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1279/5420073/6fd331e429f0/gr3.jpg

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本文引用的文献

1
Ventricular arrhythmia during ajmaline challenge for the Brugada syndrome.Brugada 综合征行阿义马林激发试验时出现室性心律失常。
Europace. 2016 Oct;18(10):1501-1506. doi: 10.1093/europace/euw008. Epub 2016 Mar 3.
2
Brugada pattern in a patient medicated with lamotrigine.使用拉莫三嗪治疗的患者出现Brugada波型。
Rev Port Cardiol. 2013 Oct;32(10):807-10. doi: 10.1016/j.repc.2013.01.009. Epub 2013 Sep 17.
3
Coexistence of epilepsy and Brugada syndrome in a family with SCN5A mutation.一家系存在 SCN5A 基因突变致癫痫和 Brugada 综合征共存
拉莫三嗪对癫痫诱导的心脏钠电流I的高亲和力阻断作用；获得性心律失常的一种可能性。
Pharmaceuticals (Basel). 2022 Sep 29;15(10):1208. doi: 10.3390/ph15101208.
4
Sinus Bradycardia in an Adolescent Taking Lamotrigine.一名服用拉莫三嗪的青少年出现窦性心动过缓。
Case Rep Psychiatry. 2022 May 13;2022:3353684. doi: 10.1155/2022/3353684. eCollection 2022.
5
Lithium Toxicity from the Addition of an ACE Inhibitor with an Unexpected Type I Brugada Pattern ECG: Case Files of the Medical Toxicology Fellowship at the University of California, San Diego.联用血管紧张素转换酶抑制剂导致锂中毒并出现意外的I型Brugada波心电图：加利福尼亚大学圣地亚哥分校医学毒理学 fellowship病例档案
J Med Toxicol. 2020 Jul;16(3):321-328. doi: 10.1007/s13181-020-00773-9. Epub 2020 Apr 15.
Epilepsy Res. 2013 Aug;105(3):415-8. doi: 10.1016/j.eplepsyres.2013.02.024. Epub 2013 Mar 25.
4
Severe sodium channel blockade and cardiovascular collapse due to a massive lamotrigine overdose.由于大剂量拉莫三嗪过量，严重的钠通道阻断和心血管衰竭。
Clin Toxicol (Phila). 2011 Nov;49(9):854-7. doi: 10.3109/15563650.2011.617307. Epub 2011 Oct 5.
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Complete heart block and death following lamotrigine overdose.拉莫三嗪过量致完全性心脏阻滞并死亡。
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Brugada-like electrocardiographic pattern induced by lamotrigine toxicity.拉莫三嗪中毒诱发的类Brugada心电图模式
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Fundam Clin Pharmacol. 2000 Mar-Apr;14(2):107-17. doi: 10.1111/j.1472-8206.2000.tb00398.x.
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Cellular and molecular actions of lamotrigine: Possible mechanisms of efficacy in bipolar disorder.拉莫三嗪的细胞与分子作用：双相情感障碍中可能的疗效机制
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