Davis Genevieve, Ward Kristen, Mohiuddin Sarah
Department of Psychiatry, University of Michigan, USA.
Case Rep Psychiatry. 2022 May 13;2022:3353684. doi: 10.1155/2022/3353684. eCollection 2022.
Lamotrigine is commonly prescribed for the treatment of neurological conditions and is increasingly being prescribed for psychiatric conditions as well. Although largely well tolerated, it is known to have a number of potential side effects, and in March 2021, the FDA issued its most recent warning for the medication due to its increased risk of cardiac arrhythmias. In this report, we describe a case in which an adolescent patient was found to be bradycardic after starting lamotrigine for antidepressant augmentation, with a gradual return to normal heart rate as the medication was subsequently tapered and discontinued. Further research is needed to more accurately estimate the risk of cardiac side effects and to establish appropriate monitoring guidelines for cardiac arrhythmias in those taking lamotrigine.
拉莫三嗪通常用于治疗神经系统疾病，目前也越来越多地用于治疗精神疾病。尽管它在很大程度上耐受性良好，但已知有一些潜在的副作用。2021年3月，美国食品药品监督管理局（FDA）因其导致心律失常的风险增加，发布了关于该药物的最新警告。在本报告中，我们描述了一例青少年患者的病例，该患者在开始使用拉莫三嗪进行抗抑郁增效治疗后出现心动过缓，随着药物随后逐渐减量并停药，心率逐渐恢复正常。需要进一步研究以更准确地评估心脏副作用的风险，并为服用拉莫三嗪的患者建立适当的心律失常监测指南。
