Mohammed Shaza, Awooda Hiba A, Rayis Duria A, Hamdan Hamdan Z, Adam Ishag, Lutfi Mohamed F
Faculty of Medicine and Health Sciences, Al-Neelain University, Khartoum, Sudan.
Faculty of Medicine, University of Khartoum, Khartoum, Sudan.
Obstet Gynecol Sci. 2017 Mar;60(2):187-192. doi: 10.5468/ogs.2017.60.2.187. Epub 2017 Mar 16.
To evaluate thyroid function and hormonal profile in women with polycystic ovary syndrome (PCOS).
A case-control study was conducted at Saad Abualila Center, Khartoum, Sudan. The cases were women with confirmed PCOS based on Rotterdam criteria. The controls were infertile women with no evidence of PCOS. The socio-demographic characteristics and medical history were gathered using a questionnaire. Thyroid hormones (thyroid-stimulating hormone, free tri-iodothyronine, and free thyroxine), anti-thyroid peroxidase, and anti-thyroglobulin antibodies were measured.
While there were no significant differences in the age and haemoglobin levels of the two studied groups (55 women in each arm), body mass index was significantly higher in women with PCOS. There were no significant differences in the levels of thyroid-stimulating hormone, luteinizing hormone, follicle stimulating hormone, luteinizing hormone/follicle stimulating hormone, anti-thyroid peroxidase, anti-thyroglobulin antibodies, cholesterol, triglycerides and low-density lipoprotein cholesterol between the cases and the controls. The mean±standard deviation of free tri-iodothyronine (3.50±0.2 vs. 3.38±0.3 pg/mL, =0.040) and median (interquartile) high-density lipoprotein cholesterol (37.0 [34.0 to 42.0] vs. 35.80 [29.0 to 41.0] mg/dL, =0.015) were significantly higher in PCOS patients compared with the control group. In linear regression, PCOS (0.151 pg/mL, =0.023) and anti-thyroid peroxidase levels (-0.078 pg/mL, =0.031) were significantly associated with free tri-iodothyronine.
Free tri-iodothyronine was a significantly higher among PCOS patients compared with the control group.
评估多囊卵巢综合征（PCOS）女性的甲状腺功能和激素水平。
在苏丹喀土穆的萨阿德·阿布阿利拉中心进行了一项病例对照研究。病例为根据鹿特丹标准确诊的PCOS女性。对照为无PCOS证据的不孕女性。使用问卷收集社会人口学特征和病史。检测甲状腺激素（促甲状腺激素、游离三碘甲状腺原氨酸和游离甲状腺素）、抗甲状腺过氧化物酶和抗甲状腺球蛋白抗体。
虽然两个研究组（每组55名女性）的年龄和血红蛋白水平无显著差异，但PCOS女性的体重指数显著更高。病例组和对照组之间的促甲状腺激素、黄体生成素、卵泡刺激素、黄体生成素/卵泡刺激素、抗甲状腺过氧化物酶、抗甲状腺球蛋白抗体、胆固醇、甘油三酯和低密度脂蛋白胆固醇水平无显著差异。PCOS患者的游离三碘甲状腺原氨酸平均±标准差（3.50±0.2 vs. 3.38±0.3 pg/mL，P = 0.040）和中位数（四分位间距）高密度脂蛋白胆固醇（37.0 [34.0至42.0] vs. 35.80 [29.0至41.0] mg/dL，P = 0.015）显著高于对照组。在线性回归中，PCOS（0.151 pg/mL，P = 0.023）和抗甲状腺过氧化物酶水平（-0.078 pg/mL，P = 0.031）与游离三碘甲状腺原氨酸显著相关。
与对照组相比，PCOS患者的游离三碘甲状腺原氨酸显著更高。
