Barre J, Pfister G, Potron G, Droulle C, Baudrillard J C, Barbier P, Kher A
Département d'Anesthésie-Réanimation, C.H.U., Reims, France.
J Mal Vasc. 1987;12 Suppl B:90-5.
A series of 80 patients operated for total hip prosthesis under epidural anesthesia was randomly allocated to treatment with Kabi 2165 (n = 40): 2,500 U anti-Xa preoperatively and evening of operation and 2,500 U anti-Xa morning and evening daily up to the 9th or 10th day postoperatively, or standard heparin (n = 40): 3,750 U preoperatively and then 8 hourly, at a dose adjusted with thrombin time and cephalin + activator time, daily up to the 9th or 10th day. Phlebography was performed routinely on the 9th or 10th day. Venous thrombosis occurred in 7 patients (17.5%) in the Kabi 2165 group, including two high, potentially emboligenic, localizations (5%), and in 4 patients (10%) in the standard heparin group, including 2 potentially emboligenic clots (5%). The difference is not statistically significant (total number: p = 0.5; potentially emboligenic: p = 0.33). Pulmonary embolism did not occur. Overall tolerance, evaluated from hemoglobin and hematocrit values, intra- and post-operative bleeding and operation wound hematoma and at injection site was comparable in the two groups.
一组80例在硬膜外麻醉下接受全髋关节置换术的患者被随机分为两组进行治疗：卡比2165组（n = 40），术前及手术当晚给予2500 U抗Xa，术后每日早晚各给予2500 U抗Xa，直至术后第9天或第10天；标准肝素组（n = 40），术前给予3750 U，然后每8小时一次，根据凝血酶时间和白陶土部分凝血活酶时间调整剂量，每日给药直至术后第9天或第10天。在第9天或第10天常规进行静脉造影。卡比2165组有7例患者（17.5%）发生静脉血栓形成，其中包括2例高位、潜在致栓性的血栓形成（5%）；标准肝素组有4例患者（10%）发生静脉血栓形成，其中包括2例潜在致栓性血栓（5%）。差异无统计学意义（总体：p = 0.5；潜在致栓性：p = 0.33）。未发生肺栓塞。根据血红蛋白和血细胞比容值、术中和术后出血情况、手术伤口血肿以及注射部位评估，两组的总体耐受性相当。
