Nakamura Daisuke, Hirano Minoru, Ohta Riichiro
Toyota Central R&D Labs., Inc., Nagakute, Aichi 480-1192, Japan.
Chem Commun (Camb). 2017 Apr 6;53(29):4096-4099. doi: 10.1039/c7cc01434a.
Nontoxicities of organic solvents were predicted using Hansen solubility parameters and various truly nontoxic solvents were identified according to the prediction. The nontoxicity of solvents originates from their exhibition of poor solubility or low diffusivity toward cell constituents and good stability against hydrolytic degradation.
利用 Hansen 溶解度参数预测有机溶剂的无毒性，并根据预测结果鉴定出各种真正无毒的溶剂。溶剂的无毒性源于它们对细胞成分的低溶解性或低扩散性以及对水解降解的良好稳定性。
