Department of Material Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Nishikyo-ku, Kyoto, 615-8510, Japan.
Angew Chem Int Ed Engl. 2017 Apr 18;56(17):4853-4857. doi: 10.1002/anie.201701238. Epub 2017 Mar 27.
para-Selective C-H borylation of benzamides and pyridines has been achieved by cooperative iridium/aluminum catalysis. A combination of iridium catalysts commonly employed for arene C-H borylation and bulky aluminum-based Lewis acid catalysts provides an unprecedented strategy for controlling the regioselectivity of C-H borylation to give variously substituted (hetero)arylboronates, which are versatile synthetic intermediates for complex multi-substituted aromatic compounds.
通过铱/铝协同催化，实现了苯甲酰胺和吡啶的对位选择性 C-H 硼化反应。通常用于芳烃 C-H 硼化的铱催化剂与大位阻的铝基路易斯酸催化剂的组合，为控制 C-H 硼化的区域选择性提供了一种前所未有的策略，从而得到各种取代的（杂）芳基硼酸酯，这些硼酸酯是复杂多取代芳香化合物的多功能合成中间体。
