Yamashita Yasunobu, Biard Alan, Hanaya Kengo, Shoji Mitsuru, Sugai Takeshi
a Department of Pharmaceutical Sciences, Faculty of Pharmacy , Keio University , Tokyo , Japan.
b Department of Chemistry , Graduate School of SIGMA Clermont , Aubiere Cedex , France.
Biosci Biotechnol Biochem. 2017 Jul;81(7):1279-1284. doi: 10.1080/09168451.2017.1303362. Epub 2017 Mar 27.
Wogonin and astringin were synthesized from inexpensive chrysin and piceid in short steps. The key feature of these syntheses is site-selective transformation. The target molecules were obtained in 27 and 62% yields from the starting materials, respectively.
汉黄芩素和三叶豆苷由廉价的白杨素和白藜芦醇苷经简短步骤合成。这些合成方法的关键特征是位点选择性转化。目标分子分别以27%和62%的产率从起始原料中获得。