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基于位点选择性脱乙酰化和脱氧反应合成非瑟酮和2',4',6'-三羟基二氢查耳酮4'-O-β-新橙皮糖苷

Synthesis of fisetin and 2',4',6'-trihydroxydihyrochalcone 4'-O-β-neohesperidoside based on site-selective deacetylation and deoxygenation.

作者信息

Tsunekawa Ryuji, Hanaya Kengo, Higashibayashi Shuhei, Sugai Takeshi

机构信息

a Faculty of Pharmacy , Keio University , Tokyo , Japan.

出版信息

Biosci Biotechnol Biochem. 2018 Aug;82(8):1316-1322. doi: 10.1080/09168451.2018.1467263. Epub 2018 Apr 26.

DOI:10.1080/09168451.2018.1467263
PMID:29699439
Abstract

Fisetin and 2',4',6'-trihydroxydihyrochalcone 4'-O-β-neohesperidoside were synthesized from commercially available quercetin and naringin in five steps. The key steps are site-selective deacetylation and subsequent deoxygenation. The target molecules were obtained in 37% and 23% yields from the starting materials, respectively.

摘要

漆黄素和2',4',6'-三羟基二氢查耳酮4'-O-β-新橙皮糖苷由市售的槲皮素和柚皮苷经五步合成。关键步骤是位点选择性脱乙酰化及随后的脱氧反应。分别从起始原料以37%和23%的产率获得目标分子。

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