1 Durham Center for Health Services Research and Development in Primary Care and Division of General Internal Medicine, Department of Medicine, Duke University, Durham, North Carolina.
2 Department of Biostatistics and Bioinformatics.
J Manag Care Spec Pharm. 2017 Apr;23(4):407-411. doi: 10.18553/jmcp.2017.23.4.407.
Limited transparency exists regarding eligibility and benefits for patient financial assistance programs (PAPs).
To describe oral anticancer medication costs, insurance coverage, and the degree of financial assistance provided by PAPs.
This was a retrospective study of prescription anticancer medication costs and PAP coverage. The study used data from an academic cancer center's specialty pharmacy. Medication, cost, and coverage data were collected from the specialty pharmacy database for prescriptions filled from January 2013 to November 2015. Prescriptions with missing copayments, insurance, or financial assistance amounts were excluded. Descriptive statistics summarized prescription characteristics.
Of 9,388 anticancer medication prescriptions filled, 8,212 (87%) had complete cost data and were included. The 5 most common medications prescribed were capecitabine (20%), temozolomide (13%), enzalutamide (10%), letrozole (6%), and tamoxifen (4%). Most prescriptions were covered by commercial insurance or Part D (41.6%, n = 3,418). The median copayment was $20 per prescription (interquartile range [IQR] = $10.00-$80.30). When considering all prescriptions that received PAP assistance, the median amount of financial assistance provided by PAPs per prescription was $411.0 (IQR = $302.80-$523.40), amounting to 15% of the median prescription cash price. When considering all prescriptions, the median amount of financial assistance provided by PAPs per prescription was $0, and the mean was $79.30 (SD = $389.90).
A minority of prescriptions received financial assistance from PAPs. The proportion of financial assistance was small relative to the price billed to insurance. PAPs play a modest role in reducing anticancer prescription-related costs.
Support of this project by The Duke Biostatistics Core was made possible by Grant Number UL1TR001117 from the National Center for Advancing Translational Sciences (NCATS), a component of the National Institutes of Health (NIH), and NIH Roadmap for Medical Research. Zullig is supported by a VA Health Services Research and Development (HSR&D) Career Development Award (CDA 13-025). Zullig also reports a financial relationship with Novartis. Zafar reports financial relationships with Novartis, Genentech-Roche, and Vivor. Vlastelica, Shankaran, and Wolf have nothing to disclose. The views in this article are those of the authors and do not necessarily represent the views of the Department of Veterans Affairs, Duke University, NCATS, or NIH. This abstract was previously presented at the 2016 ASCO Annual Meeting; Chicago, Illinois; June 3-7, 2016. Study concept and design were contributed by Zafar, Zullig, and Vlastelica, with assistance from Shankaran. Vlastelica and Wolf took the lead in data collection, along with Zafar, and data interpretation was performed by Zullig, Zafar, and Wolf, along with Vlastelica and Shankaran. The manuscript was written and revised by Zullig and Zafar, along with the other authors.
关于患者经济援助计划(PAP)的资格和福利,信息透明度有限。
描述口服抗癌药物的成本、保险覆盖范围以及 PAP 提供的经济援助程度。
这是一项关于处方抗癌药物成本和 PAP 覆盖范围的回顾性研究。该研究使用了一家学术癌症中心专业药房的数据库数据。从 2013 年 1 月至 2015 年 11 月期间,从专业药房数据库中收集了处方、成本和覆盖范围数据。排除了缺少共同支付额、保险或财务援助金额的处方。描述性统计总结了处方特征。
在 9388 份抗癌药物处方中,有 8212 份(87%)具有完整的成本数据并被纳入研究。开处方最多的 5 种药物分别是卡培他滨(20%)、替莫唑胺(13%)、恩扎卢胺(10%)、来曲唑(6%)和他莫昔芬(4%)。大多数处方由商业保险或 Part D 覆盖(41.6%,n=3418)。每份处方的平均共同支付额为 20 美元(四分位间距[IQR]=10.00-80.30 美元)。考虑所有接受 PAP 援助的处方,PAP 每份处方提供的财务援助中位数为 411.0 美元(IQR=302.80-523.40 美元),占处方现金价格中位数的 15%。考虑所有处方,PAP 每份处方提供的财务援助中位数为 0 美元,平均值为 79.30 美元(SD=389.90 美元)。
只有少数处方从 PAP 获得了经济援助。相对于保险计费价格,财务援助的比例很小。PAP 在降低抗癌药物处方相关成本方面仅发挥了适度的作用。
本项目得到了美国国立卫生研究院(NIH)下属国家转化医学研究中心(NCATS)授予的 UL1TR001117 号赠款的支持,这是 Duke 生物统计学核心项目的一部分。Zullig 得到了退伍军人事务部卫生服务研究与发展(HSR&D)职业发展奖(CDA 13-025)的支持。Zullig 还报告了与诺华的财务关系。Zafar 报告了与诺华、基因泰克罗氏和 Vivor 的财务关系。Vlastelica、Shankaran 和 Wolf 没有任何可披露的信息。本文的观点是作者的观点,不一定代表退伍军人事务部、杜克大学、NCATS 或 NIH 的观点。本文摘要曾于 2016 年在芝加哥举行的第 2016 届 ASCO 年会(ASCO Annual Meeting)上发表;2016 年 6 月 3 日至 7 日。Zafar、Zullig 和 Vlastelica 提出了研究概念和设计,并在 Shankaran 的协助下进行了数据收集。Vlastelica 和 Wolf 与 Zafar 一起主导了数据收集,数据解释由 Zullig、Zafar 和 Wolf 与 Vlastelica 和 Shankaran 共同完成。手稿由 Zullig 和 Zafar 撰写和修订,其他作者也参与了修订。