Yamashita K, Nakashima M, Kajita S, Hiramatsu M, Ogawa N, Mori A, Sato M
Department of Neuropsychiatry, Okayama University Medical School, Japan.
Jpn J Psychiatry Neurol. 1987 Sep;41(3):383-5. doi: 10.1111/j.1440-1819.1987.tb01701.x.
The present study showed that DN-1417 had a dose-dependent anticonvulsant activity on El mouse seizure. This finding is consistent with other reports using the kindling model of epilepsy. Since both the El mouse and kindling preparations have been regarded as complex partial seizure with secondary generalization, endogenous brain TRH, as well as exogenous TRH, may act as an anticonvulsant substance to such a seizure type of epilepsy. Moreover, this study showed IR-TRH of the El mouse changed significantly in the striatum or hippocampus genetically or postictally without a change in the TRH receptor binding. A transient decrease in hippocampal IR-TRH after convulsion shown in this study may suggest an increased release of TRH during and after the seizure. Further studies are required to clarify the relationship between a change in the brain TRH system and seizure susceptibility in the El mouse.
本研究表明，DN - 1417对El小鼠癫痫发作具有剂量依赖性抗惊厥活性。这一发现与其他使用癫痫点燃模型的报告一致。由于El小鼠和点燃模型均被视为伴有继发性全身性发作的复杂部分性发作，内源性脑TRH以及外源性TRH可能作为针对此类癫痫发作类型的抗惊厥物质。此外，本研究表明，El小鼠的免疫反应性TRH（IR - TRH）在纹状体或海马体中发生了显著的遗传或发作后变化，而TRH受体结合未发生改变。本研究显示惊厥后海马体IR - TRH的短暂下降可能表明癫痫发作期间及发作后TRH释放增加。需要进一步研究以阐明El小鼠脑TRH系统变化与癫痫易感性之间的关系。
