Kajita S, Nakashima M, Okamoto M, Sato M, Ogawa N
Jpn J Psychiatry Neurol. 1986 Sep;40(3):345-7. doi: 10.1111/j.1440-1819.1986.tb03158.x.
We reported previously that DN-1417, a potent analog of thyrotropin-releasing hormone (TRH), suppressed both the progression of amygdaloid (AM) kindling and AM kindled seizure. To study a functional role of the cerebral TRH mechanism in AM kindling, immunoreactive TRH (IR-TRH) and specific TRH receptor binding were examined in the rat brains kindled from the left AM. The IR-TRH concentration elevated significantly in the amygdala plus piriform cortex and the hippocampus 24 and 48 hours after the AM kindled convulsion. Such an elevation of IR-TRH was not found 7 days after the last convulsion, indicating that the elevation of IR-TRH was a transient change seen after the AM kindled convulsion. By contrast, the specific TRH receptor binding in the striatum increased 48 hours, 7 and 21 days after the AM kindled convulsion. This indicates that the increase of the specific TRH binding in the striatum was a long-lasting change. The present study suggests that the change in the striatal TRH receptors may be associated with a long-lasting seizure susceptibility of AM kindled rats.
我们之前报道过，促甲状腺激素释放激素（TRH）的强效类似物DN-1417可抑制杏仁核（AM）点燃的进展以及AM点燃性癫痫发作。为研究大脑TRH机制在AM点燃中的功能作用，我们检测了从左侧AM点燃的大鼠大脑中的免疫反应性TRH（IR-TRH）和特异性TRH受体结合情况。在AM点燃惊厥后24小时和48小时，杏仁核加梨状皮质以及海马中的IR-TRH浓度显著升高。在最后一次惊厥7天后未发现IR-TRH的这种升高，这表明IR-TRH的升高是AM点燃惊厥后出现的一种短暂变化。相比之下，在AM点燃惊厥后48小时、7天和21天，纹状体中的特异性TRH受体结合增加。这表明纹状体中特异性TRH结合的增加是一种持久变化。本研究表明，纹状体TRH受体的变化可能与AM点燃大鼠的持久癫痫易感性有关。
