From the *KIMS-DDNMRC, KIMS Cancer Centre; and †Department of Medical Oncology, Regional Cancer Centre, Trivandrum, Kerala, India.
Clin Nucl Med. 2017 Jun;42(6):446-447. doi: 10.1097/RLU.0000000000001646.
Fibrous dysplasia (FD) is a benign bone lesion with a rare but potential for malignant transformation. Neither Tc-MDP nor F-FDG PET/CT can differentiate between FD and areas of malignant transformation in FD. We described a case of osteosarcoma developing in FD with selective uptake of tracer in malignant transformation areas demonstrated on a Ga-PSMA PET/CT scan. Our case highlights the ability of Ga-PSMA PET/CT to map tumor neoangiogenesis in osteosarcoma arising in FD, which can have potential implications in prognostication, possibility of antiangiogenesis-based therapeutic options, and in response assessment following chemotherapy.
纤维结构不良（FD）是一种良性骨病变，其恶性转化的可能性虽然罕见，但确实存在。Tc-MDP 和 F-FDG PET/CT 均无法区分 FD 和 FD 中的恶性转化区域。我们描述了一例在 FD 中发生的骨肉瘤病例，Ga-PSMA PET/CT 扫描显示恶性转化区域对示踪剂有选择性摄取。我们的病例强调了 Ga-PSMA PET/CT 能够在 FD 中发生的骨肉瘤中绘制肿瘤新生血管形成图谱的能力，这可能对预后、基于抗血管生成的治疗选择的可能性以及化疗后反应评估具有潜在影响。
