Bischof Joachim, Westhoff Mike-Andrew, Wagner Johanna Elisabeth, Halatsch Marc-Eric, Trentmann Stephanie, Knippschild Uwe, Wirtz Christian Rainer, Burster Timo
1 Department of General and Visceral Surgery, Surgery Center, Ulm University Medical Center, Ulm University, Ulm, Germany.
2 Department Pediatrics and Adolescent Medicine, Ulm University Medical Center, Ulm University, Ulm, Germany.
Tumour Biol. 2017 Mar;39(3):1010428317692227. doi: 10.1177/1010428317692227.
One major obstacle in cancer therapy is chemoresistance leading to tumor recurrence and metastasis. Cancer stem cells, in particular glioblastoma stem cells, are highly resistant to chemotherapy, radiation, and immune recognition. In case of immune recognition, several survival mechanisms including, regulation of autophagy, proteases, and cell surface major histocompatibility complex class I molecules, are found in glioblastoma stem cells. In different pathways, cathepsins play a crucial role in processing functional proteins that are necessary for several processes and proper cell function. Consequently, strategies targeting these pathways in glioblastoma stem cells are promising approaches to interfere with tumor cell survival and will be discussed in this review.
癌症治疗中的一个主要障碍是化疗耐药性，这会导致肿瘤复发和转移。癌症干细胞，尤其是胶质母细胞瘤干细胞，对化疗、放疗和免疫识别具有高度抗性。在免疫识别的情况下，胶质母细胞瘤干细胞中发现了几种生存机制，包括自噬调节、蛋白酶以及细胞表面主要组织相容性复合体I类分子。在不同的途径中，组织蛋白酶在加工多种过程和正常细胞功能所需的功能性蛋白质方面发挥着关键作用。因此，针对胶质母细胞瘤干细胞中这些途径的策略是干扰肿瘤细胞生存的有前景的方法，本文将对此进行讨论。
