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谷氨酸和去甲肾上腺素的相互作用：与更高阶认知运作和精神病理学的关联。

Glutamate and norepinephrine interaction: Relevance to higher cognitive operations and psychopathology.

机构信息

Clinical Neurosciences Division,VA National Center for PTSD,VA Connecticut Healthcare System,West Haven,CT 06516.

出版信息

Behav Brain Sci. 2016 Jan;39:e201. doi: 10.1017/S0140525X15001727.

DOI:10.1017/S0140525X15001727
PMID:28347382
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5485236/
Abstract

Mather and colleagues present an impressive interdisciplinary model of arousal-induced norepinephrine release and its role in selectively enhancing/inhibiting perception, attention, and memory consolidation. This model will require empirical investigation to test its validity and generalizability beyond classic norepinephrine circuits because it simplifies extremely complex and heterogeneous actions including norepinephrine mechanisms related to higher cognitive circuits and psychopathology.

摘要

马瑟及其同事提出了一个令人印象深刻的、跨学科的唤醒诱导去甲肾上腺素释放模型，以及它在选择性增强/抑制感知、注意力和记忆巩固方面的作用。这个模型需要通过实证研究来检验其有效性和普遍性，因为它简化了极其复杂和异质的作用，包括与高级认知回路和精神病理学相关的去甲肾上腺素机制。

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Glutamate and norepinephrine interaction: Relevance to higher cognitive operations and psychopathology.谷氨酸和去甲肾上腺素的相互作用：与更高阶认知运作和精神病理学的关联。
Behav Brain Sci. 2016 Jan;39:e201. doi: 10.1017/S0140525X15001727.
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本文引用的文献

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Targeting Prefrontal Cortical Systems for Drug Development: Potential Therapies for Cognitive Disorders.以额叶前皮质系统为靶点进行药物研发：认知障碍的潜在疗法
Annu Rev Pharmacol Toxicol. 2016;56:339-60. doi: 10.1146/annurev-pharmtox-010715-103617.
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Stress weakens prefrontal networks: molecular insults to higher cognition.压力会削弱前额叶网络：对高级认知的分子损伤。
Nat Neurosci. 2015 Oct;18(10):1376-85. doi: 10.1038/nn.4087. Epub 2015 Sep 25.
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Norepinephrine ignites local hotspots of neuronal excitation: How arousal amplifies selectivity in perception and memory.去甲肾上腺素点燃神经元兴奋的局部热点：唤醒如何增强感知和记忆的选择性。
Behav Brain Sci. 2016 Jan;39:e200. doi: 10.1017/S0140525X15000667. Epub 2015 Jul 1.
4
The Effects of Stress Exposure on Prefrontal Cortex: Translating Basic Research into Successful Treatments for Post-Traumatic Stress Disorder.应激暴露对前额叶皮质的影响：将基础研究转化为创伤后应激障碍的成功治疗方法。
Neurobiol Stress. 2015 Jan 1;1:89-99. doi: 10.1016/j.ynstr.2014.10.002.
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Rapid-acting glutamatergic antidepressants: the path to ketamine and beyond.快速作用的谷氨酸抗抑郁药：从氯胺酮到其他药物的探索之路。
Biol Psychiatry. 2013 Jun 15;73(12):1133-41. doi: 10.1016/j.biopsych.2013.03.026.
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NMDA receptors subserve persistent neuronal firing during working memory in dorsolateral prefrontal cortex.NMDA 受体在后外侧前额叶皮层的工作记忆中持续激发神经元放电。
Neuron. 2013 Feb 20;77(4):736-49. doi: 10.1016/j.neuron.2012.12.032.
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Neuromodulation of thought: flexibilities and vulnerabilities in prefrontal cortical network synapses.思想的神经调节：前额皮质网络突触的灵活性和脆弱性。
Neuron. 2012 Oct 4;76(1):223-39. doi: 10.1016/j.neuron.2012.08.038.
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