谷氨酸和去甲肾上腺素的相互作用：与更高阶认知运作和精神病理学的关联。
Glutamate and norepinephrine interaction: Relevance to higher cognitive operations and psychopathology.
机构信息
Clinical Neurosciences Division,VA National Center for PTSD,VA Connecticut Healthcare System,West Haven,CT 06516.
出版信息
Behav Brain Sci. 2016 Jan;39:e201. doi: 10.1017/S0140525X15001727.
Abstract
Mather and colleagues present an impressive interdisciplinary model of arousal-induced norepinephrine release and its role in selectively enhancing/inhibiting perception, attention, and memory consolidation. This model will require empirical investigation to test its validity and generalizability beyond classic norepinephrine circuits because it simplifies extremely complex and heterogeneous actions including norepinephrine mechanisms related to higher cognitive circuits and psychopathology.
摘要
马瑟及其同事提出了一个令人印象深刻的、跨学科的唤醒诱导去甲肾上腺素释放模型，以及它在选择性增强/抑制感知、注意力和记忆巩固方面的作用。这个模型需要通过实证研究来检验其有效性和普遍性，因为它简化了极其复杂和异质的作用，包括与高级认知回路和精神病理学相关的去甲肾上腺素机制。
相似文献
1
Glutamate and norepinephrine interaction: Relevance to higher cognitive operations and psychopathology.谷氨酸和去甲肾上腺素的相互作用：与更高阶认知运作和精神病理学的关联。
Behav Brain Sci. 2016 Jan;39:e201. doi: 10.1017/S0140525X15001727.
2
Norepinephrine ignites local hotspots of neuronal excitation: How arousal amplifies selectivity in perception and memory.去甲肾上腺素点燃神经元兴奋的局部热点：唤醒如何增强感知和记忆的选择性。
Behav Brain Sci. 2016 Jan;39:e200. doi: 10.1017/S0140525X15000667. Epub 2015 Jul 1.
3
Bodily arousal differentially impacts stimulus processing and memory: Norepinephrine in interoception.躯体唤醒会对刺激加工和记忆产生差异影响：去甲肾上腺素在躯体感觉中的作用。
Behav Brain Sci. 2016 Jan;39:e205. doi: 10.1017/S0140525X15001764.
4
The Fluency Amplification Model supports the GANE principle of arousal enhancement.流畅度增强模型支持 GANE 唤醒增强原则。
Behav Brain Sci. 2016 Jan;39:e204. doi: 10.1017/S0140525X15001752.
5
GANEing traction: The broad applicability of NE hotspots to diverse cognitive and arousal phenomena.获得牵引力：NE 热点对各种认知和唤醒现象的广泛适用性。
Behav Brain Sci. 2016 Jan;39:e228. doi: 10.1017/S0140525X16000017.
6
What do we GANE with age?我们随着年龄的增长会得到什么？
Behav Brain Sci. 2016 Jan;39:e218. doi: 10.1017/S0140525X15001892.
7
Emotional memory: From affective relevance to arousal.情绪记忆：从情感相关性到唤醒。
Behav Brain Sci. 2016 Jan;39:e216. doi: 10.1017/S0140525X15001879.
8
Pharmacological manipulation of memory reconsolidation: towards a novel treatment of pathogenic memories.记忆再巩固的药理学调控：迈向对病理性记忆的新型治疗
Eur J Pharmacol. 2008 May 13;585(2-3):453-7. doi: 10.1016/j.ejphar.2008.03.010. Epub 2008 Mar 18.
9
Arousal amplifies biased competition between high and low priority memories more in women than in men: The role of elevated noradrenergic activity.与男性相比，觉醒在女性中更能增强高优先级和低优先级记忆之间的偏向竞争：去甲肾上腺素能活性升高的作用。
Psychoneuroendocrinology. 2017 Jun;80:80-91. doi: 10.1016/j.psyneuen.2017.02.022. Epub 2017 Feb 24.
10
Noradrenergic Modulation of Cognition in Health and Disease.健康与疾病状态下认知的去甲肾上腺素能调节
Neural Plast. 2017;2017:6031478. doi: 10.1155/2017/6031478. Epub 2017 May 3.
引用本文的文献
1
Pharmacological target sites for restoration of age-associated deficits in NMDA receptor-mediated norepinephrine release in brain.恢复大脑中NMDA受体介导的去甲肾上腺素释放与年龄相关缺陷的药理学靶点
J Neurochem. 2025 Jan;169(1):e16280. doi: 10.1111/jnc.16280.
2
An Activatable F MRI Molecular Probe for Sensing and Imaging of Norepinephrine.一种用于检测和成像去甲肾上腺素的可激活 fMRI 分子探针。
ChemistryOpen. 2022 Jul;11(7):e202200110. doi: 10.1002/open.202200110. Epub 2022 Jun 28.
3
Activity of Selected Group of Monoterpenes in Alzheimer's Disease Symptoms in Experimental Model Studies-A Non-Systematic Review.在实验模型研究中，选择的单萜类化合物对阿尔茨海默病症状的活性：非系统性综述。
Int J Mol Sci. 2021 Jul 8;22(14):7366. doi: 10.3390/ijms22147366.
4
The Locus Coeruleus- Norepinephrine System in Stress and Arousal: Unraveling Historical, Current, and Future Perspectives.应激与觉醒中的蓝斑-去甲肾上腺素系统：解读历史、现状与未来展望
Front Psychiatry. 2021 Jan 27;11:601519. doi: 10.3389/fpsyt.2020.601519. eCollection 2020.
5
Targeting Inflammatory-Mitochondrial Response in Major Depression: Current Evidence and Further Challenges.靶向治疗重度抑郁症中的炎症-线粒体反应：现有证据与未来挑战
Oxid Med Cell Longev. 2020 Apr 14;2020:2972968. doi: 10.1155/2020/2972968. eCollection 2020.
6
The Neurobiology and Pharmacotherapy of Posttraumatic Stress Disorder.创伤后应激障碍的神经生物学与药物治疗。
Annu Rev Pharmacol Toxicol. 2019 Jan 6;59:171-189. doi: 10.1146/annurev-pharmtox-010818-021701. Epub 2018 Sep 14.
本文引用的文献
1
Targeting Prefrontal Cortical Systems for Drug Development: Potential Therapies for Cognitive Disorders.以额叶前皮质系统为靶点进行药物研发：认知障碍的潜在疗法
Annu Rev Pharmacol Toxicol. 2016;56:339-60. doi: 10.1146/annurev-pharmtox-010715-103617.
2
Stress weakens prefrontal networks: molecular insults to higher cognition.压力会削弱前额叶网络：对高级认知的分子损伤。
Nat Neurosci. 2015 Oct;18(10):1376-85. doi: 10.1038/nn.4087. Epub 2015 Sep 25.
3
Norepinephrine ignites local hotspots of neuronal excitation: How arousal amplifies selectivity in perception and memory.去甲肾上腺素点燃神经元兴奋的局部热点：唤醒如何增强感知和记忆的选择性。
Behav Brain Sci. 2016 Jan;39:e200. doi: 10.1017/S0140525X15000667. Epub 2015 Jul 1.
4
The Effects of Stress Exposure on Prefrontal Cortex: Translating Basic Research into Successful Treatments for Post-Traumatic Stress Disorder.应激暴露对前额叶皮质的影响：将基础研究转化为创伤后应激障碍的成功治疗方法。
Neurobiol Stress. 2015 Jan 1;1:89-99. doi: 10.1016/j.ynstr.2014.10.002.
5
Rapid-acting glutamatergic antidepressants: the path to ketamine and beyond.快速作用的谷氨酸抗抑郁药：从氯胺酮到其他药物的探索之路。
Biol Psychiatry. 2013 Jun 15;73(12):1133-41. doi: 10.1016/j.biopsych.2013.03.026.
6
NMDA receptors subserve persistent neuronal firing during working memory in dorsolateral prefrontal cortex.NMDA 受体在后外侧前额叶皮层的工作记忆中持续激发神经元放电。
Neuron. 2013 Feb 20;77(4):736-49. doi: 10.1016/j.neuron.2012.12.032.
7
Neuromodulation of thought: flexibilities and vulnerabilities in prefrontal cortical network synapses.思想的神经调节：前额皮质网络突触的灵活性和脆弱性。
Neuron. 2012 Oct 4;76(1):223-39. doi: 10.1016/j.neuron.2012.08.038.
8
Alpha2A-adrenoceptors strengthen working memory networks by inhibiting cAMP-HCN channel signaling in prefrontal cortex.α2A肾上腺素能受体通过抑制前额叶皮质中的环磷酸腺苷-超极化激活的环核苷酸门控通道信号来增强工作记忆网络。
Cell. 2007 Apr 20;129(2):397-410. doi: 10.1016/j.cell.2007.03.015.
9
Protein kinase C overactivity impairs prefrontal cortical regulation of working memory.蛋白激酶C活性过高会损害前额叶皮质对工作记忆的调节。
Science. 2004 Oct 29;306(5697):882-4. doi: 10.1126/science.1100021.
10
Differential modulatory effects of norepinephrine on synaptically driven responses of layer V barrel field cortical neurons.去甲肾上腺素对V层桶状皮层神经元突触驱动反应的差异性调节作用。
Brain Res. 2000 Jun 16;868(1):39-47. doi: 10.1016/s0006-8993(00)02261-7.
Zotero 插件