Bansinath M, Fisher J S, Tang C K, Turndorf H, Puig M M
Department of Anesthesiology, NYU Medical Center, New York, NY 10016.
Pharmacol Biochem Behav. 1988 Mar;29(3):609-12. doi: 10.1016/0091-3057(88)90027-5.
The effects of morphine, fentanyl, sufentanil and droperidol on motor coordination in mice were studied. Animals were trained to complete successfully the rotarod test before assessing the effects of drugs. Administration of analgesic doses of the mu agonists morphine, fentanyl and sufentanil did not inhibit motor coordination. Droperidol produced a dose related inhibition of motor coordination. When a subthreshold dose of droperidol was administered followed by an opiate, a significant inhibition of motor coordination was observed. The results indicate that although analgesic doses of mu opioid agonists do not affect motor coordination, their combination with droperidol results in motor incoordination. The mechanisms and/or opioid receptor sub-types involved in this in vivo interaction remain to be established.
研究了吗啡、芬太尼、舒芬太尼和氟哌利多对小鼠运动协调性的影响。在评估药物作用之前，先训练动物成功完成转棒试验。给予μ阿片受体激动剂吗啡、芬太尼和舒芬太尼的镇痛剂量并未抑制运动协调性。氟哌利多产生了与剂量相关的运动协调性抑制作用。当给予亚阈剂量的氟哌利多后再给予阿片类药物时，观察到运动协调性受到显著抑制。结果表明，虽然μ阿片受体激动剂的镇痛剂量不影响运动协调性，但它们与氟哌利多联合使用会导致运动不协调。这种体内相互作用所涉及的机制和/或阿片受体亚型仍有待确定。
