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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Statile L, Puig M M, Warner W, Bansinath M, Lovitz M, Turndorf H

Department of Anesthesiology, New York University Medical Center, NY 10016.

Gen Pharmacol. 1988;19(3):451-4. doi: 10.1016/0306-3623(88)90046-8.

The effect of droperidol pre-treatment on the analgesic potency of morphine, fentanyl and sufentanil was assessed in mice. 2. Acetic acid writhing test and tail immersion test were used to measure the analgesic response. 3. The neuroleptic augments the effects of sufentanil and fentanyl. 4. Thus, the dose-response curves for fentanyl and sufentanil were shifted to the left and the ED50 of the analgesics lowered in droperidol pre-treated animals. 5. However, morphine analgesia was not influenced by droperidol. 6. The results suggest that combination of sufentanil or fentanyl with droperidol may be better than morphine to produce neuroleptanalgesia and anesthesia.

在小鼠中评估了氟哌利多预处理对吗啡、芬太尼和舒芬太尼镇痛效力的影响。2. 采用醋酸扭体试验和热板试验来测量镇痛反应。3. 该抗精神病药增强了舒芬太尼和芬太尼的作用。4. 因此，在氟哌利多预处理的动物中，芬太尼和舒芬太尼的剂量反应曲线向左移动，镇痛药的半数有效剂量降低。5. 然而，吗啡镇痛不受氟哌利多影响。6. 结果表明，舒芬太尼或芬太尼与氟哌利多联合使用可能比吗啡更有利于产生神经安定镇痛和麻醉。

Statile L, Puig M M, Warner W, Bansinath M, Lovitz M, Turndorf H

Department of Anesthesiology, New York University Medical Center, NY 10016.

Gen Pharmacol. 1988;19(3):451-4. doi: 10.1016/0306-3623(88)90046-8.

The effect of droperidol pre-treatment on the analgesic potency of morphine, fentanyl and sufentanil was assessed in mice. 2. Acetic acid writhing test and tail immersion test were used to measure the analgesic response. 3. The neuroleptic augments the effects of sufentanil and fentanyl. 4. Thus, the dose-response curves for fentanyl and sufentanil were shifted to the left and the ED50 of the analgesics lowered in droperidol pre-treated animals. 5. However, morphine analgesia was not influenced by droperidol. 6. The results suggest that combination of sufentanil or fentanyl with droperidol may be better than morphine to produce neuroleptanalgesia and anesthesia.

在小鼠中评估了氟哌利多预处理对吗啡、芬太尼和舒芬太尼镇痛效力的影响。2. 采用醋酸扭体试验和热板试验来测量镇痛反应。3. 该抗精神病药增强了舒芬太尼和芬太尼的作用。4. 因此，在氟哌利多预处理的动物中，芬太尼和舒芬太尼的剂量反应曲线向左移动，镇痛药的半数有效剂量降低。5. 然而，吗啡镇痛不受氟哌利多影响。6. 结果表明，舒芬太尼或芬太尼与氟哌利多联合使用可能比吗啡更有利于产生神经安定镇痛和麻醉。