Kanof P D, Davidson M, Johns C A, Mohs R C, Davis K L
Psychiatry Service, Bronx VA Medical Center, NY 10468.
Am J Psychiatry. 1987 Dec;144(12):1556-60. doi: 10.1176/ajp.144.12.1556.
A diminished cAMP response to prostaglandin E1 (PGE1) in platelets from schizophrenic patients has been demonstrated previously. The authors report that among 35 actively psychotic male schizophrenic patients, the platelet cAMP response to PGE1 was negatively correlated with global symptom severity and with several indexes of positive symptom severity but not with negative symptom severity. If this subsensitivity of platelet PGE receptors extends to brain PGE receptors, schizophrenic patients may have an impairment in the ability of endogenous PGEs to inhibit dopaminergic transmission. Such impairment could have a permissive effect on the production of psychotic symptoms during exacerbations in schizophrenic patients.
先前已证明，精神分裂症患者血小板对前列腺素E1（PGE1）的环磷酸腺苷（cAMP）反应减弱。作者报告称，在35名处于活动期精神病性症状的男性精神分裂症患者中，血小板对PGE1的cAMP反应与总体症状严重程度以及几个阳性症状严重程度指标呈负相关，但与阴性症状严重程度无关。如果血小板PGE受体的这种亚敏感性扩展至脑PGE受体，那么精神分裂症患者内源性PGEs抑制多巴胺能传递的能力可能受损。这种损害可能对精神分裂症患者病情加重期间精神病性症状的产生具有促成作用。
