巨噬细胞功能在慢性淋巴细胞白血病中的双重性。
The duality of macrophage function in chronic lymphocytic leukaemia.
机构信息
University of Queensland Diamantina Institute, University of Queensland, Translational Research Institute, Princess Alexandra Hospital, Brisbane, Qld, Australia.
Department of Haematology, Division of Cancer Services, Princess Alexandra Hospital, Brisbane, Qld, Australia.
出版信息
Biochim Biophys Acta Rev Cancer. 2017 Aug;1868(1):176-182. doi: 10.1016/j.bbcan.2017.03.006. Epub 2017 Mar 24.
Chronic lymphocytic leukaemia (CLL) is the most common adult leukaemia and, in some patients, is accompanied by resistance to both chemotherapeutics and immunotherapeutics. In this review we will discuss the role of tumour associated macrophages (TAMs) in promoting CLL cell survival and resistance to immunotherapeutics. In addition, we will discuss mechanisms by which TAMs suppress T-cell mediated antitumour responses. Thus, targeting macrophages could be used to i) reduce the leukaemic burden via the induction of T-cell-mediated antitumour responses, ii) to reduce pro-survival signalling and enhance response to conventional chemotherapeutics or iii) enhance the response to therapeutic antibodies in current clinical use.
慢性淋巴细胞白血病（CLL）是最常见的成人白血病，在某些患者中，对化疗药物和免疫疗法均有耐药性。在这篇综述中，我们将讨论肿瘤相关巨噬细胞（TAMs）在促进 CLL 细胞存活和对免疫疗法耐药中的作用。此外，我们还将讨论 TAMs 抑制 T 细胞介导的抗肿瘤反应的机制。因此，靶向巨噬细胞可用于：i）通过诱导 T 细胞介导的抗肿瘤反应来减少白血病负担，ii）降低生存信号并增强对常规化疗药物的反应，或 iii）增强当前临床应用的治疗性抗体的反应。
Zotero 插件