白血病微环境中的巨噬细胞
Macrophages in leukemia microenvironment.
作者信息
Wang Lina, Zheng Guoguang
机构信息
State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China.
出版信息
Blood Sci. 2019 Sep 17;1(1):29-33. doi: 10.1097/BS9.0000000000000014. eCollection 2019 Aug.
Abstract
Macrophages, the important component of tissue microenvironment, play important roles in both physiological and pathological processes, including tumor and leukemia. Tumor-associated macrophages are involved in tumor proliferation, angiogenesis, invasion, metastasis, and chemotherapy resistance. In leukemia, macrophages are educated by leukemia microenvironment to obtain specific activated phenotype and participate in leukemia progression. Recent studies have shown that accumulation of macrophages in leukemia patients or mouse model is correlated with poor prognosis. Hence, increasing attentions have been paid to study the characteristics of them and to develop novel therapeutic strategies targeting macrophages against leukemia. In this article, we summarize recent development of macrophages in leukemia microenvironment.
摘要
巨噬细胞是组织微环境的重要组成部分，在包括肿瘤和白血病在内的生理和病理过程中发挥着重要作用。肿瘤相关巨噬细胞参与肿瘤增殖、血管生成、侵袭、转移和化疗耐药。在白血病中，巨噬细胞受白血病微环境影响而获得特定的活化表型，并参与白血病进展。最近的研究表明，白血病患者或小鼠模型中巨噬细胞的积累与预后不良相关。因此，人们越来越关注研究它们的特性，并开发针对巨噬细胞的新型抗白血病治疗策略。在本文中，我们总结了白血病微环境中巨噬细胞的最新研究进展。
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