Rosenbloom Brittany N, McCartney Colin J L, Canzian Sonya, Kreder Hans J, Katz Joel
Institute of Medical Science, Department of Anesthesia, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada; Department of Anesthesia, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada; Department of Psychology, Faculty of Health, York University, Toronto, Ontario, Canada.
Institute of Medical Science, Department of Anesthesia, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada; Department of Anesthesia, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.
J Pain. 2017 Aug;18(8):956-963. doi: 10.1016/j.jpain.2017.03.006. Epub 2017 Mar 25.
The aim of the present study was to examine the incidence and predictors of persistent prescription opioid use 4 months after traumatic injury. Adults who sustained a traumatic musculoskeletal injury were recruited to participate in this observational prospective, longitudinal study within 14 days of injury (T1) and followed for 4 months (T2). Measures included questionnaires on pain, opioid consumption, pain disability, anxiety, depression, and posttraumatic stress symptoms as well as a chart review for injury related information. The sample consisted of 122 patients (66.4% male; mean age = 44.8 years, SD = 17.1), of whom 94.3% (n = 115) were using prescription opioids. At T2, 35.3% (n = 43) patients were using prescription opioids. After controlling for age, sex, injury severity, T1 pain severity, and T2 symptoms of depression, 2 factors emerged as significantly related to T2 prescription opioid use; namely, T2 pain severity (odds ratio = 1.248, 95% confidence interval, 1.071-1.742) and T2 pain self-efficacy (odds ratio = .943, 95% confidence interval, .903-.984). These results suggest that opioid use after traumatic musculoskeletal injury is related to pain severity and how well patients cope specifically with their pain, over and above other psychological factors, such as depression and anxiety.
This article identifies predictive factors for prescription opioid use after traumatic musculoskeletal injury, namely severe pain and a poor sense of control over the pain. These results highlight the importance of using prospective longitudinal study designs to understand why patients continue to use prescription opioids after major tissue-damaging events.
本研究的目的是调查创伤性损伤4个月后持续使用处方阿片类药物的发生率及预测因素。招募遭受创伤性肌肉骨骼损伤的成年人,在受伤后14天内(T1)参与这项观察性前瞻性纵向研究,并随访4个月(T2)。测量指标包括关于疼痛、阿片类药物使用量、疼痛残疾、焦虑、抑郁和创伤后应激症状的问卷,以及对损伤相关信息的病历审查。样本包括122名患者(66.4%为男性;平均年龄 = 44.8岁,标准差 = 17.1),其中94.3%(n = 115)正在使用处方阿片类药物。在T2时,35.3%(n = 43)的患者仍在使用处方阿片类药物。在控制了年龄、性别、损伤严重程度、T1时的疼痛严重程度和T2时的抑郁症状后,有2个因素与T2时处方阿片类药物的使用显著相关;即T2时的疼痛严重程度(比值比 = 1.248,95%置信区间,1.071 - 1.742)和T2时的疼痛自我效能感(比值比 = 0.943,95%置信区间,0.903 - 0.984)。这些结果表明,创伤性肌肉骨骼损伤后阿片类药物的使用与疼痛严重程度以及患者应对疼痛的能力有关,而不仅仅与其他心理因素如抑郁和焦虑有关。
本文确定了创伤性肌肉骨骼损伤后处方阿片类药物使用的预测因素,即严重疼痛和对疼痛的控制感差。这些结果凸显了使用前瞻性纵向研究设计来理解患者在重大组织损伤事件后为何继续使用处方阿片类药物的重要性。