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Pure motor axonal neuropathy triggered by antituberculous therapy in an undiagnosed case of acute intermittent porphyria.抗结核治疗引发的纯运动性轴索性神经病，发生在一例未确诊的急性间歇性卟啉病患者中。
BMJ Case Rep. 2017 Mar 27;2017:bcr2016219105. doi: 10.1136/bcr-2016-219105.
2
[Recurrent abdominal pain caused by acute intermittent porphyria].[急性间歇性卟啉病引起的复发性腹痛]
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[Acute intermittent porphyria: a diagnostic dilemma].[急性间歇性卟啉病：诊断难题]
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Acute intermittent porphyria: a missed diagnosis in pre-pubertal children with recurrent abdominal pain.急性间歇性卟啉病：青春期前反复腹痛儿童的漏诊疾病。
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[Acute intermittent porphyria. A clinical chameleon: case study of a 40-year-old female patient].
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Drug-associated porphyria: a pharmacovigilance study.药物相关性卟啉病：一项药物警戒研究。
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Acute Porphyrias.急性卟啉病
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Best practice guidelines on clinical management of acute attacks of porphyria and their complications.急性卟啉症发作及其并发症的临床管理最佳实践指南。
Ann Clin Biochem. 2013 May;50(Pt 3):217-23. doi: 10.1177/0004563212474555.
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Drugs in porphyria: From observation to a modern algorithm-based system for the prediction of porphyrogenicity.卟啉症相关药物：从观察到基于现代算法的卟啉症预测系统。
Pharmacol Ther. 2011 Nov;132(2):158-69. doi: 10.1016/j.pharmthera.2011.06.001. Epub 2011 Jun 16.
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Acute intermittent porphyria associated with respiratory failure: a multidisciplinary approach.急性间歇性卟啉病伴呼吸衰竭：多学科诊疗方法
Crit Care Res Pract. 2011;2011:283690. doi: 10.1155/2011/283690. Epub 2011 May 11.
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Antituberculosis drugs: drug interactions, adverse effects, and use in special situations. Part 1: first-line drugs.抗结核药物：药物相互作用、不良反应及特殊情况下的应用。第 1 部分：一线药物。
J Bras Pneumol. 2010 Sep-Oct;36(5):626-40. doi: 10.1590/s1806-37132010000500016.
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Porphyrias.卟啉症。
Lancet. 2010 Mar 13;375(9718):924-37. doi: 10.1016/S0140-6736(09)61925-5.
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Identifying acute porphyria in patients with acute polyneuropathy or encephalopathy.在急性多发性神经病或脑病患者中识别急性卟啉病。
Nat Clin Pract Neurol. 2008 Dec;4(12):648-9. doi: 10.1038/ncpneuro0946. Epub 2008 Nov 11.
8
Antituberculosis drug-induced hepatotoxicity: concise up-to-date review.抗结核药物所致肝毒性：简明最新综述
J Gastroenterol Hepatol. 2008 Feb;23(2):192-202. doi: 10.1111/j.1440-1746.2007.05207.x. Epub 2007 Nov 6.
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Porphyrias.卟啉病
Lancet. 2005;365(9455):241-52. doi: 10.1016/S0140-6736(05)17744-7.
10
Porphyric neuropathy.卟啉性神经病
Muscle Nerve. 2004 Oct;30(4):410-22. doi: 10.1002/mus.20137.

抗结核治疗引发的纯运动性轴索性神经病，发生在一例未确诊的急性间歇性卟啉病患者中。

Pure motor axonal neuropathy triggered by antituberculous therapy in an undiagnosed case of acute intermittent porphyria.

作者信息

Babar Masood Uz Zaman, Hakeem Haris, Khan Sara

机构信息

Department of Neurology, Aga Khan University Hospital, Karachi, Pakistan.

Aga Khan University Hospital, Karachi, Pakistan.

出版信息

BMJ Case Rep. 2017 Mar 27;2017:bcr2016219105. doi: 10.1136/bcr-2016-219105.

DOI:10.1136/bcr-2016-219105
PMID:28348263
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5372185/
Abstract

A man aged 22 years misdiagnosed as suffering from recurrent abdominal tuberculosis, in view of recurrent abdominal pain was treated for abdominal tuberculosis in the past. The patient was prescribed antituberculous therapy. 2 months after starting treatment, he developed progressive weakness of all 4 limbs. Electrodiagnostic examination revealed an acute severe motor axonal neuropathy. Further workup revealed elevated porphyrin precursors in urine.

摘要

一名22岁男性曾因反复腹痛被误诊为复发性腹部结核，过去接受过腹部结核治疗，当时给他开了抗结核治疗药物。开始治疗2个月后，他出现了四肢进行性无力。电诊断检查显示为急性严重运动轴索性神经病。进一步检查发现尿中卟啉前体升高。