[对在羟基磷灰石上分级分离的染色质蛋白质异质性的分析]
[Analysis of the heterogeneity of chromatin proteins fractionated on hydroxyapatite].
作者信息
Dubrovskiĭ I B, Khrapunov S N
出版信息
Ukr Biokhim Zh (1978). 1988 Jan-Feb;60(1):8-13.
PMID:2834848
Abstract
The protein composition of the liver chromatin has been studied by two techniques for fractionation of histones. The "lability" fraction of histones H2A-H2B is revealed. In these fractions histones H2B have many modified forms and they are not included into octamer (H3, H4, H2A, H2B)2. Young animals rather than old ones have much quantitative subfractions of histone H2B. The "lability" fraction of histones H2A-H2B is stated to be very significant in the activated and repressed chromatin structure.
摘要
通过两种组蛋白分级分离技术研究了肝脏染色质的蛋白质组成。发现了组蛋白H2A - H2B的“不稳定”组分。在这些组分中，组蛋白H2B有许多修饰形式，并且它们不包含在八聚体（H3、H4、H2A、H2B）2中。幼龄动物而非老龄动物的组蛋白H2B定量亚组分更多。据指出，组蛋白H2A - H2B的“不稳定”组分在活化和抑制的染色质结构中非常重要。
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