Farha Khalid Abou, AbouFarha Ramy, Bolt Marc
PRA-International, Institute for Clinical Pharmacology, Groningen, Netherlands.
Dr. Nassau College, Grammar School, Assen, Netherlands.
Cardiol Res. 2011 Apr;2(2):58-65. doi: 10.4021/cr24e. Epub 2011 Mar 25.
The acute impact of tobacco smoking on the cardiac hemodynamic parameters and its pathological implication in the process of arterial atherosclerosis need further exploration. This investigation was purposed to assess the acute impact of tobacco smoke on blood pressure and cardiac hemodynamic parameters.
Using an Ultrasonic Cardiac Output Monitor, and DINAMAP Pro 400 Series V2 blood pressure monitor, several cardiac hemodynamic parameters and the blood pressure were assessed in 14 smokers, 11 females and 3 males, at 2 time points, before and after smoking of one cigarette. Data, in terms of ratio of the means and 95% confidence interval were analyzed using ANOVA.
Single-subject design in which the subject has served as his/her own control has been used. Tobacco smoking led to statistically significant acute increase in the means of all hemodynamic parameters, except for heart rate in female subjects, as compared to the means obtained before smoking.
Cigarette smoking induces acute non-physiologic alteration in cardiac outflow forces, exposing the aortic valve and arch to mechanical injury that might be implicated in initiating and promoting the process of aortic arch atherosclerosis and associated pathological lesions.
吸烟对心脏血流动力学参数的急性影响及其在动脉粥样硬化过程中的病理意义尚需进一步探究。本研究旨在评估吸烟对血压和心脏血流动力学参数的急性影响。
使用超声心输出量监测仪和DINAMAP Pro 400系列V2血压监测仪，在14名吸烟者（11名女性和3名男性）吸一支烟前后的两个时间点，对多个心脏血流动力学参数和血压进行评估。采用方差分析对均值比和95%置信区间的数据进行分析。
采用单受试者设计，受试者自身作为对照。与吸烟前测得的均值相比，吸烟导致除女性受试者心率外的所有血流动力学参数均值出现统计学上的显著急性升高。
吸烟会引起心脏流出力的急性非生理性改变，使主动脉瓣和主动脉弓受到机械损伤，这可能与启动和促进主动脉弓动脉粥样硬化过程及相关病理病变有关。
